Histidinol-phosphatase

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histidinol-phosphatase
2yz5.jpg
Histidinol-phosphatase tetramer, Thermus thermophilus
Identifiers
EC number 3.1.3.15
CAS number 9025-79-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a histidinol-phosphatase (EC 3.1.3.15) is an enzyme that catalyzes the chemical reaction

L-histidinol phosphate + H2O L-histidinol + phosphate

Thus, the two substrates of this enzyme are L-histidinol phosphate and H2O, whereas its two products are L-histidinol and phosphate.

This enzyme participates in histidine metabolism.

Nomenclature[edit]

This enzyme belongs to the family of hydrolases, to be specific, those acting on phosphoric monoester bonds. The systematic name of this enzyme class is L-histidinol-phosphate phosphohydrolase. Other names in common use include histidinol phosphate phosphatase, L-histidinol phosphate phosphatase, histidinolphosphate phosphatase, HPpase, and histidinolphosphatase.

E. coli[edit]

In E. coli the enzyme encoded by the gene hisB is a fused imidazoleglycerol-phosphate dehydratase and histidinol-phosphatase.[1]

References[edit]

  1. ^ Brilli M, Fani R (February 2004). "Molecular evolution of hisB genes". Journal of Molecular Evolution. 58 (2): 225–37. doi:10.1007/s00239-003-2547-x. PMID 15042344. 

Further reading[edit]

  • Ames BN (June 1957). "The biosynthesis of histidine; L-histidinol phosphate phosphatase". The Journal of Biological Chemistry. 226 (2): 583–93. PMID 13438843.