|PDB structures||RCSB PDB PDBe PDBsum|
|Gene Ontology||AmiGO / QuickGO|
- L-histidinol phosphate + 2-oxoglutarate 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-histidinol-phosphate:2-oxoglutarate aminotransferase. Other names in common use include imidazolylacetolphosphate transaminase, glutamic-imidazoleacetol phosphate transaminase, histidinol phosphate aminotransferase, imidazoleacetol phosphate transaminase, L-histidinol phosphate aminotransferase, histidine:imidazoleacetol phosphate transaminase, IAP transaminase, and imidazolylacetolphosphate aminotransferase. This enzyme participates in 5 metabolic pathways: histidine metabolism, tyrosine metabolism, phenylalanine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, and novobiocin biosynthesis. It employs one cofactor, pyridoxal phosphate.
- AMES BN, HORECKER BL (1956). "The biosynthesis of histidine: imidazoleacetol phosphate transaminase". J. Biol. Chem. 220 (1): 113–28. PMID 13319331.
- Martin RG; Goldberger RF (1963). "Imidazolylacetolphosphate:L-glutamate aminotransferase. Purification and properties". J. Biol. Chem. 242 (6): 1168–1174. PMID 5337155.