Histone deacetylase 2

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HDAC2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HDAC2, HD2, RPD3, YAF1, histone deacetylase 2
External IDs MGI: 1097691 HomoloGene: 68187 GeneCards: 3066
RNA expression pattern
PBB GE HDAC2 201833 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001527

NM_008229

RefSeq (protein)

NP_001518.3

NP_032255.2

Location (UCSC) Chr 6: 113.93 – 114.01 Mb Chr 10: 36.97 – 37 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the HDAC2 gene.[1]

Function[edit]

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events.[2]

Interactions[edit]

Histone deacetylase 2 has been shown to interact with:

See also[edit]

References[edit]

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Further reading[edit]

External links[edit]