D-glycero-beta-D-manno-heptose-7-phosphate kinase

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D-glycero-beta-D-manno-heptose-7-phosphate kinase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

D-glycero-beta-D-manno-heptose-7-phosphate kinase (EC, heptose 7-phosphate kinase, D-beta-D-heptose 7-phosphotransferase, D-beta-D-heptose-7-phosphate kinase, HldE1 heptokinase, glycero-manno-heptose 7-phosphate kinase, D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase, hldE (gene), rfaE (gene)) is an enzyme with systematic name ATP:D-glycero-beta-D-manno-heptose 7-phosphate 1-phosphotransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

D-glycero-beta-D-manno-heptose 7-phosphate + ATP D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP

The bifunctional protein hldE includes D-glycero-beta-D-manno-heptose-7-phosphate kinase and D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC


  1. ^ McArthur, F.; Andersson, C.E.; Loutet, S.; Mowbray, S.L.; Valvano, M.A. (2005). "Functional analysis of the glycero-manno-heptose 7-phosphate kinase domain from the bifunctional HldE protein, which is involved in ADP-L-glycero-D-manno-heptose biosynthesis". J. Bacteriol. 187: 5292–5300. doi:10.1128/jb.187.15.5292-5300.2005. PMC 1196024Freely accessible. PMID 16030223. 
  2. ^ Kneidinger, B.; Marolda, C.; Graninger, M.; Zamyatina, A.; McArthur, F.; Kosma, P.; Valvano, M.A.; Messner, P. (2002). "Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli". J. Bacteriol. 184: 363–369. doi:10.1128/jb.184.2.363-369.2002. PMC 139585Freely accessible. PMID 11751812. 
  3. ^ Valvano, M.A.; Messner, P.; Kosma, P. (2002). "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides". Microbiology. 148: 1979–1989. doi:10.1099/00221287-148-7-1979. PMID 12101286. 
  4. ^ Jin, U.H.; Chung, T.W.; Lee, Y.C.; Ha, S.D.; Kim, C.H. (2001). "Molecular cloning and functional expression of the rfaE gene required for lipopolysaccharide biosynthesis in Salmonella typhimurium". Glycoconj. J. 18: 779–787. PMID 12441667. 
  5. ^ Wang, L.; Huang, H.; Nguyen, H.H.; Allen, K.N.; Mariano, P.S.; Dunaway-Mariano, D. (2010). "Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB)". Biochemistry. 49: 1072–1081. doi:10.1021/bi902018y. PMC 2844805Freely accessible. PMID 20050615. 

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