Hofbauer cell

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Hofbauer cells are oval eosinophilic histiocytes[1] with granules and vacuoles found in the placenta, which are of mesenchymal origin, in mesoderm of the chorionic villus, particularly numerous in early pregnancy.

Etymology[edit]

They are named after J. Isfred Isidore Hofbauer, an American gynecologist. (1878-1961)[1]

Function[edit]

They are believed to be a type of macrophage[2][3] and are most likely involved in preventing the transmission of pathogens from the mother to the fetus (so-called vertical transmission). Although there are many studies concerning placental vasculogenesis and angiogenesis, there has been a lack of evidence on the possible roles of Hofbauer cells in these processes.[4] According to a systems level single-cell transcriptomics based study of human placental cell-cell communication, Hofbauer cells produce HBEGF, an EGFR ligand, which drives differentiation of villous cytotrophoblasts (VCT) towards syncytiotrophoblasts (SCT)[5].

Histology[edit]

Micrograph of chorionic villi with Hofbauer cells. H&E stain.

Under histology sections, Hofbauer cells have appeared with discernible amount of cytoplasm.

See also[edit]

References[edit]

  1. ^ a b Venes, Donald (2006). Taber's cyclopedic medical dictionary (Ed. 20, illustrated in full color. ed.). Philadelphia [Pa.]: Davis Co. ISBN 0-8036-1208-7.
  2. ^ Wood, GW. "Mononuclear phagocytes in the human placenta". Placenta. 1 (2): 113–23. doi:10.1016/s0143-4004(80)80019-1. PMID 7003580.
  3. ^ Zaccheo, D.; Pistoia, V.; Castellucci, M.; Martinoli, C. (1989). "Isolation and characterization of Hofbauer cells from human placental villi". Arch Gynecol Obstet. 246 (4): 189–200. doi:10.1007/bf00934518. PMID 2482706.
  4. ^ Seval, Y.; Korgun, ET.; Demir, R. "Hofbauer cells in early human placenta: possible implications in vasculogenesis and angiogenesis". Placenta. 28 (8–9): 841–5. doi:10.1016/j.placenta.2007.01.010. PMID 17350092.
  5. ^ Vento-Tormo, Roser; Efremova, Mirjana; Botting, Rachel A.; Turco, Margherita Y.; Vento-Tormo, Miquel; Meyer, Kerstin B.; Park, Jong-Eun; Stephenson, Emily; Polański, Krzysztof; Goncalves, Angela; Gardner, Lucy; Holmqvist, Staffan; Henriksson, Johan; Zou, Angela; Sharkey, Andrew M.; Millar, Ben; Innes, Barbara; Wood, Laura; Wilbrey-Clark, Anna; Payne, Rebecca P.; Ivarsson, Martin A.; Lisgo, Steve; Filby, Andrew; Rowitch, David H.; Bulmer, Judith N.; Wright, Gavin J.; Stubbington, Michael J. T.; Haniffa, Muzlifah; Moffett, Ashley; Teichmann, Sarah A. (2018). "Single-cell reconstruction of the early maternal–fetal interface in humans". Nature. 563 (7731): 347–353. doi:10.1038/s41586-018-0698-6. ISSN 0028-0836.