Hole-board test

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The hole-board test is a rodent model test for measuring head-dipping activity in experimental animals. Changes in head-dipping activity have been considered to be related to anxiety by some researchers.[1][2] The hole-board apparatus consists of an enclosed space, the floor of which has sixteen holes in a grid-pattern.[3] The rodent, when placed in the apparatus, is free to dip its head through the holes in the floor; the frequency and duration of this behaviour, known as 'head-dipping' is thought to measure levels of neophilia.[4] Such experiments are used in the field of behavioural pharmacology.[5]


  1. ^ Takeda, H.; Tsuji, M.; Matsumiya, T. (1998). "Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice". European Journal of Pharmacology 350 (1): 21–29. doi:10.1016/S0014-2999(98)00223-4. PMID 9683010.  edit
  2. ^ Bilkei-Gorzó, A.; Gyertyán, I. (1996). "Some doubts about the basic concept of hole-board test". Neurobiology (Budapest, Hungary) 4 (4): 405–415. PMID 9200132.  edit
  3. ^
  4. ^ File and Wardill, 1975a; Ljungberg and Ungerstedt, 1976
  5. ^ Pharmacological and genetic influences on hole-board behaviors in mice Kliethermes CL, Crabbe JC Pharmacol Biochem Behav. 2006 Sep; 85(1):57-65. [PubMed] [Ref list]

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