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Temporal range: Middle Pleistocene to Recent
Scientific classification
Kingdom: Animalia
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Cricetidae
Genus: Holochilus
Brandt, 1835

Holochilus brasiliensis
Holochilus chacarius
Holochilus sciureus

Holochilus is a genus of semiaquatic rodents in the tribe Oryzomyini of family Cricetidae, sometimes called marsh rats. It contains three living species, Holochilus brasiliensis, Holochilus chacarius, and Holochilus sciureus, which are widely distributed in South America east of the Andes, and a fourth species from the Pleistocene of Bolivia, Holochilus primigenus.