|Merocrine or eccrine – by exocytosis|
|Apocrine – by membrane budding (loss of cytoplasm)|
|Holocrine – by membrane rupture|
Holocrine is a term used to classify the mode of secretion in exocrine glands in the study of histology. Holocrine secretions are produced in the cytoplasm of the cell and released by the rupture of the plasma membrane, which destroys the cell and results in the secretion of the product into the lumen.
Examples of holocrine glands include the sebaceous glands of the skin and the meibomian glands of the eyelid. The sebaceous gland is an example of a holocrine gland because its product of secretion (sebum) is released with remnants of dead cells.
- Victor Eroschenko, diFiore's Atlas of Histology with functional correlations, Lippincot Williams and Wilkins, 10th edition, 2005. p. 41