Homeostatic capacity

From Wikipedia, the free encyclopedia

Homeostatic capacity refers to the capability of systems to self-stabilize in response to external forces or stressors, or more simply the capability of systems to maintain homeostasis.[1][2] For living organisms, it is life's foundational trait, consisting of a hierarchy and network of traits endowed by nature and shaped by natural selection. Homeostatic capacity comprises a multidimensional network of traits and operates at all scales of biology systems levels including molecular, cellular, physiological, and organismal.

Human homeostatic capacity[edit]

In the context of human beings, homeostatic capacity refers to the inherent ability of the body to self-stabilize in response to external and internal stimuli. Homeostatic capacity of the human body erodes with age.[3][4][5]

Homeostatic capacity and aging[edit]

A hypothesis proffered by the proponents of the Palo Alto Longevity Prize is that the array of ailments associated with aging may be epiphenomena of eroding homeostatic capacity and the process of aging may be halted or reversed by restoring homeostatic capacity to that of a healthy young adult.[6][7][8][9][10]

See also[edit]


  1. ^ Anthony Joonkyoo Yun, MD (2014). Hiding in Plain Sight: Essays by Joon Yun, MD, Second Edition. p. 130. ISBN 9781312492028.
  2. ^ "After the last death: Doctors, academics debate the possibility, value of a 150-year lifespan". Palo Alto Online. January 9, 2015. Retrieved January 13, 2015.
  3. ^ Novoseltsev VN, Novoseltseva J, Yashin AI (2001). "A homeostatic model of oxidative damage explains paradoxes observed in earlier aging experiments: a fusion and extension of older theories of aging". Biogerontology. 2 (2): 127–38. doi:10.1023/a:1011511100472. PMID 11708379. S2CID 6542650.
  4. ^ Rolls BJ, Phillips PA (March 1990). "Aging and disturbances of thirst and fluid balance". Nutr Rev. 48 (3): 137–44. doi:10.1111/j.1753-4887.1990.tb02915.x. PMID 2406645.
  5. ^ Phillips, Paddy A.; Hodsman, G. Peter; Johnston, Colin I. (January 1991). "Neuroendocrine mechanisms and cardiovascular homeostasis in the elderly". Cardiovascular Drugs and Therapy. 4 (S6): 1209–1213. doi:10.1007/BF00114221. PMID 2009244. S2CID 32343396.
  6. ^ "FAQ – Palo Alto Longevity Prize". Palo Alto Longevity Prize. Retrieved October 1, 2014.
  7. ^ Ashlee Vance (September 9, 2014). "Silicon Valley Investor Backs $1 Million Prize to End Death". Bloomberg Businessweek. Retrieved October 1, 2014.
  8. ^ "$1 Million Longevity Prize Seeks To "Hack The Aging Code"" (Press release). Yahoo! Finance. September 9, 2014. Retrieved October 1, 2014.
  9. ^ Aaron Kinney (September 14, 2014). "Silicon Valley launches another bid to 'hack' aging, cheat death". San Jose Mercury News. Retrieved October 1, 2014.
  10. ^ Victoria Thorp (November 23, 2014). "The Palo Alto Prize: A 'Moonshot' at Increasing Longevity". Palo Alto Pulse. Retrieved December 8, 2014.