Homoserine O-succinyltransferase

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homoserine O-succinyltransferase
2vdj.jpg
Homoserine O-acetyltransferase dimer, Bacillus cereus
Identifiers
EC number2.3.1.46
CAS number62213-51-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a homoserine O-succinyltransferase (EC 2.3.1.46) is an enzyme that catalyzes the chemical reaction

succinyl-CoA + L-homoserine CoA + O-succinyl-L-homoserine

Thus, the two substrates of this enzyme are succinyl-CoA and L-homoserine, whereas its two products are CoA and O-succinyl-L-homoserine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:L-homoserine O-succinyltransferase. Other names in common use include homoserine O-transsuccinylase, and homoserine succinyltransferase. This enzyme participates in methionine metabolism and sulfur metabolism.

Structural studies[edit]

As of late 2016, three structures have been solved for this class of enzymes, with PDB accession codes 2GHR, 2H2W, and 2VDJ.

References[edit]

  • Rowbury RJ, Woods DD (September 1964). "O-SUCCINYLHOMOSERINE AS AN INTERMEDIATE IN THE SYNTHESIS OF CYSTATHIONINE BY ESCHERICHIA COLI". Journal of General Microbiology. 36: 341–58. doi:10.1099/00221287-36-3-341. PMID 14217349.