HopC RNA motif

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hopC RNA
HopC-RNA.svg
Consensus secondary structure of hopC RNAs
Identifiers
Symbol hopC RNA
Rfam RF01741
Other data
RNA type Cis-regulatory element
Domain(s) Helicobacter

The hopC RNA motif is a predicted cis-regulatory element identified by a bioinformatic screen for conserved RNA secondary structures.[1] hopC RNAs are exclusively found within bacteria classified within the genus Helicobacter, some of which are human pathogens that infect the stomach and can cause ulcers.

hopC RNAs are found upstream of an operon of two genes called hopC and hopB (also called alpa and alpB). Experiments on the start of transcription for the hopCB operon[2] indicate that hopC RNAs lie within the 5' untranslated region of this operon. The hopCB operon is induced to higher levels of expression in response to low pH.[2] This fits in with data that HopCB is involved in binding to human epithelial cells,[3] which is presumably something that the bacteria do during infection of the low-pH environment of the stomach.

Previous work suggested that a repeat of 13 thymidine nucleotides might be involved in regulating the abundance of the hopCB operon.[2] However, this 13-nucleotide region lies upstream of the transcription start site, and is therefore independent of hopC motif RNAs.

References[edit]

  1. ^ Weinberg Z, Wang JX, Bogue J, et al. (March 2010). "Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea and their metagenomes". Genome Biol. 11 (3): R31. PMC 2864571Freely accessible. PMID 20230605. doi:10.1186/gb-2010-11-3-r31. 
  2. ^ a b c McGowan CC, Necheva AS, Forsyth MH, Cover TL, Blaser MJ (June 2003). "Promoter analysis of Helicobacter pylori genes with enhanced expression at low pH". Mol. Microbiol. 48 (5): 1225–39. PMID 12787351. doi:10.1046/j.1365-2958.2003.03500.x. 
  3. ^ Odenbreit S, Faller G, Haas R (September 2002). "Role of the alpAB proteins and lipopolysaccharide in adhesion of Helicobacter pylori to human gastric tissue". Int. J. Med. Microbiol. 292 (3–4): 247–56. PMID 12398215. doi:10.1078/1438-4221-00204. 

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