Mutationism is one of several alternatives to evolution by natural selection that have existed both before and after the publication of Charles Darwin's 1859 book, On the Origin of Species. In the theory, mutation was the source of novelty, creating new forms and new species, potentially instantaneously, in sudden jumps. This was envisaged as driving evolution, which was thought to be limited by the supply of mutations.
Before Darwin, biologists commonly believed in saltationism, the possibility of large evolutionary jumps, including immediate speciation. For example, in 1822 Étienne Geoffroy Saint-Hilaire argued that species could be formed by sudden transformations, or what would later be called macromutation. Darwin opposed saltation, insisting on gradualism in evolution as in geology (uniformitarianism). In 1864, Albert von Kölliker revived Geoffroy's theory. In 1901 the geneticist Hugo de Vries gave the name "mutation" to seemingly new forms that suddenly arose in his experiments on the evening primrose Oenothera lamarckiana, and in the first decade of the 20th century, mutationism, or as de Vries named it mutationstheorie, became a rival to Darwinism supported for a while by geneticists including William Bateson, Thomas Hunt Morgan, and Reginald Punnett.
Understanding of mutationism is clouded by the mid-20th century portrayal of the early mutationists by supporters of the modern synthesis as opponents of Darwinian evolution and rivals of the biometrics school who argued that selection operated on continuous variation. In this portrayal, mutationism was defeated by a synthesis of genetics and natural selection that supposedly started later, around 1918, with work by the mathematician Ronald Fisher. However, the alignment of Mendelian genetics and natural selection began as early as 1902 with a paper by Udny Yule, and built up with theoretical and experimental work in Europe and America. Despite the controversy, the early mutationists had by 1918 already accepted natural selection and explained continuous variation as the result of multiple genes acting on the same characteristic, such as height.
Mutationism, along with other alternatives to Darwinism like Lamarckism and orthogenesis, was discarded by most biologists as they came to see that Mendelian genetics and natural selection could readily work together; mutation took its place as a source of the genetic variation essential for natural selection to work on. However, mutationism did not entirely vanish. In 1940, Richard Goldschmidt again argued for single-step speciation by macromutation, describing the organisms thus produced as "hopeful monsters", earning widespread ridicule. In 1987, Masatoshi Nei argued controversially that evolution was often mutation-limited. Modern biologists such as Douglas J. Futuyma conclude that essentially all claims of evolution driven by large mutations can be explained by Darwinian evolution.
Developments leading up to mutationism
Geoffroy's monstrosities, 1822
Prior to Charles Darwin, most naturalists were saltationists,[a] believing that species evolved and that speciation took place in sudden jumps. Jean-Baptiste Lamarck was a gradualist but similar to other scientists of the period had written that saltational evolution was possible.
In 1822, in the second volume of his Philosophie anatomique, Étienne Geoffroy Saint-Hilaire endorsed a theory of saltational evolution that "monstrosities could become the founding fathers (or mothers) of new species by instantaneous transition from one form to the next." Geoffroy wrote that environmental pressures could produce sudden transformations to establish new species instantaneously.
Darwin's anti-saltationist gradualism, 1859
In his 1859 book On the Origin of Species, Charles Darwin denied saltational evolution. He argued that evolutionary transformation always proceeds gradually, never in jumps: "natural selection acts solely by accumulating slight successive favourable variations, it can produce no great or sudden modification; it can act only by very short steps". Darwin continued in this belief throughout his life.
Thomas Henry Huxley warned Darwin that he had taken on "an unnecessary difficulty in adopting Natura non facit saltum ["Nature does not take leaps"] so unreservedly." Huxley feared this assumption could discourage naturalists (catastrophists) who believed that major leaps and cataclysms played a significant role in the history of life.
von Kölliker's heterogenesis, 1864
In 1864 Albert von Kölliker revived Geoffroy's theory that evolution proceeds by large steps, under the name of heterogenesis, but this time assuming the influence of a nonmaterial force[b] to direct the course of evolution.
Galton's "sports", 1892
Darwin's cousin, Francis Galton, considered Darwin's evidence for evolution, and came to an opposite conclusion about the type of variation on which natural selection must act. He carried out his own experiments and published a series of papers and books setting out his views. Already by 1869 when he published Hereditary Genius, he believed in evolution by saltation. In his 1889 book Natural Inheritance he argued that natural selection would benefit from accepting that the steps need not, as Darwin had stated, be minute. In his 1892 book Finger Prints, he stated directly that "The progress of evolution is not a smooth and uniform progression, but one that proceeds by jerks, through successive 'sports' (as they are called), some of them implying considerable organic changes; and each in its turn being favoured by Natural Selection".
From 1860 to 1880 saltation had been a minority viewpoint, to the extent that Galton felt his writings were being universally ignored. By 1890 it became a widely held theory, and his views helped to launch a major controversy.
Bateson's discontinuous variation, 1894
William Bateson's 1894 book Materials for the Study of Variation, Treated with Especial Regard to Discontinuity in the Origin of Species marked the arrival of mutationist thinking, before the rediscovery of Mendel's laws. He examined discontinuous variation (implying a form of saltation) where it occurred naturally, following William Keith Brooks, Galton, Thomas Henry Huxley and St. George Jackson Mivart.
Early 20th century mutationism
De Vries and Mendelian mutationstheorie, 1901
The main principle of the mutation theory is that species and varieties have originated by mutation, but are, at present, not known to have originated in any other way. — Hugo de Vries
Hugo de Vries's careful 1901 studies of wild variants of the evening primrose Oenothera lamarckiana showed that distinct new forms could arise suddenly in nature, apparently at random, and could be propagated for many generations without dissipation or blending. He gave such changes the name "mutation".[c] By this, de Vries meant that a new form of the plant was created in a single step (not the same as a mutation in the modern sense); no long period of natural selection was required for speciation, and nor was reproductive isolation. In the view of the historian of science Peter J. Bowler, De Vries used the term to mean
large-scale genetic changes capable of producing a new subspecies, or even species, instantaneously.
The historian of science Betty Smocovitis described mutationism as
De Vries set out his position, known as Mutationstheorie (mutation theory) on the creative nature of mutation in his 1905 book Species and Varieties: their Origin by Mutation. In the view of the historian of science Edward Larson, de Vries was the person largely responsible for transforming Victorian era saltationism into early 20th century mutation theory, "and in doing so pushed Darwinism near the verge of extinction as a viable scientific theory".
Johannsen's "pure line" experiments, 1903
In the early 1900s, Darwin's mechanism of natural selection was understood by believers in continuous variation, principally the biometricians Walter Weldon and Karl Pearson, to be able to work on a continuously varying characteristic, whereas de Vries argued that selection on such characteristics would be ineffective. Wilhelm Johannsen's "pure line" experiments on Phaseolus vulgaris beans appeared to refute this mechanism. Using the true-breeding Princess variety of bean, carefully inbred within weight classes, Johannsen's work appeared to support de Vries. The offspring had a smooth random distribution. Johanssen believed that his results showed that continuous variability was not inherited, so evolution must rely on discontinuous mutations, as de Vries had argued. Johanssen published his work in Danish in a 1903 paper Om arvelighed i samfund og i rene linier (On inheritance in populations and in pure lines), and in his 1905 book Arvelighedslærens Elementer (The Elements of Heredity).
Punnett's mimicry, 1915
In 1915, Reginald Punnett argued in his book Mimicry in Butterflies that the 3 morphs (forms) of the butterfly Papilio polytes, which mimic different host species of butterfly, demonstrated discontinuous evolution in action. The different forms existed in a stable polymorphism controlled by 2 Mendelian factors (genes). The alleles of these genes were certainly discontinuous, so Punnett supposed that they must have evolved in discontinuous leaps.
The undermining of mutationism
Yule's analysis of Mendelism and continuous variation, 1902
The undermining of mutationism began almost at once, in 1902, as the statistician Udny Yule analysed Mendel's theory and showed that given full dominance of one allele over another, a 3:1 ratio of alleles would be sustained indefinitely. This meant that the recessive allele could remain in the population with no need to invoke mutation. He also showed that given multiple factors, Mendel's theory enabled continuous variation, as indeed Mendel had suggested, removing the central plank of the mutationist theory, and criticised Bateson's confrontational approach. However, the "excellent" paper did not prevent the Mendelians and the biometricians from falling out.
Nilsson-Ehle's experiments on Mendelian inheritance and continuous variation, 1908
The Swedish geneticist H. Nilsson-Ehle demonstrated in 1908, in a paper published in German in a Swedish journal, Einige Ergebnisse von Kreuzungen bei Hafer und Weizen (Observations on Crosses in Oats and Wheat), that continuous variation could readily be produced by multiple Mendelian genes. He found numerous Mendelian 3:1 ratios, implying a dominant and a recessive allele, in oats and wheat; a 15:1 ratio for a cross of oat varieties with black and white glumes respectively, implying two pairs of alleles (two Mendelian factors); and that crossing a red-grained Swedish velvet wheat with a white one gave in the third (F3) generation the complex signature of ratios expected of three factors at once, with 37 grains giving only red offspring, 8 giving 63:1 in their offspring, 12 giving 15:1, and 6 giving 3:1. There weren't any grains giving all white, but as he had only expected 1 of those in his sample, 0 was not an unlikely outcome. Genes could clearly combine in almost infinite combinations: ten of his factors allowed for almost 60,000 different forms, with no need to suppose that any new mutations were involved. The results implied that natural selection would work on Mendelian genes, helping to bring about the unification of Darwinian evolution and genetics.
Similar work in America by Edward East on maize in 1910 showed the same thing for biologists without access to Nilsson-Ehle's work. On the same theme, the mathematician Ronald Fisher published "The Correlation Between Relatives on the Supposition of Mendelian Inheritance" in 1918, again showing that continuous variation could readily be produced by multiple Mendelian genes. It showed, too, that Mendelian inheritance had no essential link with mutationism: Fisher stressed that small variations (per gene) would be sufficient for natural selection to drive evolution.
Castle's selection experiments on hooded rats, 1911
Starting in 1906, William Castle carried out a long study of the effect of selection on coat colour in rats. The piebald or hooded pattern was recessive to the grey wild type. He crossed hooded rats with the black-backed Irish type, and then back-crossed the offspring with pure hooded rats. The dark stripe on the back was bigger. He then tried selecting different groups for bigger or smaller stripes for 5 generations, and found that it was possible to change the characteristics way beyond the initial range of variation. This effectively refuted de Vries's claim that continuous variation could not be inherited permanently, requiring new mutations. By 1911 Castle noted that the results could be explained by Darwinian selection on heritable variation of Mendelian genes.
Morgan's small Mendelian genes in Drosophila, 1912
By 1912, after years of work on the genetics of Drosophila fruit flies, Thomas Hunt Morgan showed that these animals had many small Mendelian factors on which Darwinian evolution could work as if variation was fully continuous. The way was open for geneticists to conclude that Mendelism supported Darwinism.
Muller's balanced lethal explanation of Oenothera "mutations", 1918
De Vries's mutationism was dealt a serious if not fatal blow in 1918 by the American geneticist Hermann Joseph Muller. He compared the behaviour of balanced lethals in Drosophila with De Vries's supposed mutations in Oenothera, showing that they could work the same way. No actual mutations were involved, but infrequent chromosome crossovers accounted for the sudden appearance of traits which had been present in the genes all along.
Fisher's explanation of polymorphism, 1927
In 1927, Fisher explicitly attacked Punnett's 1915 theory of discontinuous evolution of mimicry. Fisher argued that selection acting on genes making small modifications to the butterfly's phenotype (its appearance) would allow the multiple forms of a polymorphism to be established.
Later mutationist theories
The understanding that Mendelian genetics could both preserve discrete variations indefinitely, and support continuous variation for natural selection to work on gradually, meant that most biologists from around 1918 onwards accepted natural selection as the driving force of evolution. Mutationism and other alternatives to evolution by natural selection did not however vanish entirely.
Berg's nomogenesis, 1922
Lev Berg proposed a combination of mutationism and directed (orthogenetic) evolution in his 1922 book Nomogenesis; or, Evolution Determined by Law. He used evidence from paleontology, zoology, and botany to argue that natural selection had limitations which set a direction for evolution. He claimed that speciation was caused by "mass transformation of a great number of individuals" by directed mass mutations.
Willis's macromutations, 1923
In 1923, the botanist John Christopher Willis proposed that species were formed by large mutations, not gradual evolution by natural selection, and that evolution was driven by orthogenesis, which he called "differentiation", rather than by natural selection.
Goldschmidt's hopeful monsters, 1940
In his 1940 book The Material Basis of Evolution, the German geneticist Richard Goldschmidt argued for single-step speciation by macromutation, describing the organisms thus produced as "hopeful monsters". Goldschmidt's thesis was universally rejected and widely ridiculed by biologists, who favoured the neo-Darwinian explanations of Fisher, J. B. S. Haldane and Sewall Wright. However, interest in Goldschmidt's ideas has reawakened in the field of evolutionary developmental biology.
Nei's mutation-driven evolution, 1987
Contemporary biologists accept that mutation and selection both play roles in evolution; the mainstream view is that while mutation supplies material for selection in the form of variation, all non-random outcomes are caused by natural selection. Masatoshi Nei argues instead that the production of more efficient genotypes by mutation is fundamental for evolution, and that evolution is often mutation-limited. Nei's book received thoughtful reviews; while Wright, in the conservative journal Evolution, rejected Nei's thinking as mistaken, Galtier, Weiss, Stoltzfus, and Wagner, although not necessarily agreeing with Nei's position, treated it as a relevant alternative view.
Reviewing the history of macroevolutionary theories, the American evolutionary biologist Douglas J. Futuyma notes that since 1970, two very different alternatives to Darwinian gradualism have been proposed, both by Stephen Jay Gould: mutationism, and punctuated equilibria. Gould's macromutation theory gave a nod to his predecessor with an envisaged "Goldschmidt break" between evolution within a species and speciation. His advocacy of Goldschmidt was attacked with "highly unflattering comments" by Brian Charlesworth and Alan Templeton. Futuyma concludes, following other biologists reviewing the field such as K.Sterelny and A. Minelli, that essentially all the claims of evolution driven by large mutations could be explained within the Darwinian evolutionary synthesis. James A. Shapiro's claim that molecular genetics undermines Darwinism has been described as mutationism and an extreme view by the zoologist Andy Gardner.
Biologists at the start of the 20th century broadly agreed that evolution occurred, but felt that the mechanisms suggested by Darwin, including natural selection, would be ineffective. Large mutations looked likely to drive evolution quickly, and avoided the difficulty which had rightly worried Darwin, namely that blending inheritance would average out any small favourable changes.[d] Further, large saltatory mutation, able to create species in a single step, offered a ready explanation of why the fossil record should contain large discontinuities and times of rapid change.
These discoveries were often framed by supporters of the mid-20th century modern synthesis, such as Julian Huxley and Ernst Mayr, as a controversy between the early geneticists—the "Mendelians"—including Bateson, Johannsen, de Vries, Morgan, and Punnett, who advocated Mendelism and mutation, and were understood as opponents of Darwin's original gradualist view, and the biometricians such as Pearson and Weldon, who opposed Mendelism and were more faithful to Darwin. In this version, little progress was made during the eclipse of Darwinism, and the debate between mutationist geneticists such as de Vries and biometricians such as Pearson ended with the victory of the modern synthesis between about 1918 and 1950. According to this account, the new population genetics of the 1940s demonstrated the explanatory power of natural selection, while mutationism, alongside other non-Darwinian approaches such as orthogenesis and structuralism, was essentially abandoned. This view became dominant in the second half of the 20th century, and was accepted by both biologists and historians.
A more recent view, advocated by the historians Arlin Stoltzfus and Kele Cable, is that Bateson, de Vries, Morgan and Punnett had by 1918 formed a synthesis of Mendelism and mutationism. The understanding achieved by these geneticists spanned the action of natural selection on alleles (alternative forms of a gene), the Hardy-Weinberg equilibrium, the evolution of continuously-varying traits (like height), and the probability that a new mutation will become fixed. In this view, the early geneticists accepted natural selection alongside mutation, but rejected Darwin's non-Mendelian ideas about variation and heredity, and the synthesis began soon after 1900. The traditional claim that Mendelians rejected the idea of continuous variation outright is simply false; as early as 1902, Bateson and Edith Saunders wrote that "If there were even so few as, say, four or five pairs of possible allelomorphs, the various homo- and hetero-zygous combinations might, on seriation, give so near an approach to a continuous curve, that the purity of the elements would be unsuspected".
Historians have interpreted the history of mutationism in different ways.The classical view is that mutationism, opposed to Darwin's gradualism, was an obvious error; the decades-long delay in synthesizing genetics and Darwinism is an "inexplicable embarrassment"; genetics led logically to the modern synthesis and mutationism was one of several anti-Darwinian "blind alleys" separate from the main line leading from Darwin to the present. A revisionist view is that mutationists accepted both mutation and selection, with broadly the same roles they have today, and early on accepted and indeed offered a correct explanation for continuous variation based on multiple genes, paving the way for gradual evolution. At the time of the Darwin centennial in Cambridge in 1909, mutationism and Lamarckism were contrasted with natural selection as competing ideas; 50 years later, at the 1959 University of Chicago centennial of the publication of On the Origin of Species, mutationism was no longer seriously considered.
- The term mutation was not used in biology until the 20th century, but macromutation and saltation are essentially equivalent descriptions.
- Orthogenesis, possibly vitalism.
- The changes in the evening primrose were later shown to be caused by chromosome duplications (polyploidy) rather than gene mutation.
- Mendelian inheritance, with discrete alleles, solves Darwin's problem, as blending does not occur.
- Bowler, Peter J. (1992) . The Eclipse of Darwinism. p. 198. ISBN 978-0-8018-4391-4.
- Smocovitis 1996, p. 56.
- Dawkins, Richard (1999) . Unweaving the Rainbow. Penguin. p. 195. ISBN 978-0-14-026408-1.
- Osborn, Henry Fairfield (1894). From the Greeks to Darwin: An outline of the development of the evolution idea. Macmillan. pp. 228–250.
- Bowler 1989, p. 83.
- Hallgrímsson, Benedikt; Hall, Brian K. (2011). Variation: A Central Concept in Biology. Academic Press. p. 18. ISBN 978-0-12-088777-4.
- Bowler 2003, p. 127.
- Darwin, Charles (1859). On the Origin of Species (PDF). p. 471.
- Thomas Henry Huxley. (1859). Letter to Charles Darwin. Nov. 23, 1859.
- Gould, Stephen J. (1977). "The Return of Hopeful Monsters". Natural History. 86 (24): 30.
- Wright, Sewall (1984). Evolution and the Genetics of Populations: Genetics and Biometric Foundations Volume 1. University of Chicago Press. p. 10. ISBN 978-0226910383.
- Provine 2001, p. 24
- Provine 2001, pp. 14–24
- Radick, Gregory (2008). The Simian Tongue: The Long Debate about Animal Language. University Of Chicago Press. p. 368. ISBN 978-0226702247.
- Levit, Georgy S.; Meister, Kay; Hoßfeld, Uwe (2008). "Alternative evolutionary theories: A historical survey". Journal of Bioeconomics. 10 (1): 71–96. doi:10.1007/s10818-008-9032-y.
- Bateson, William (1894). Materials for the Study of Variation, Treated with Especial Regard to Discontinuity in the Origin of Species. Macmillan.
- Gillham, Nicholas W. (December 2001). "Evolution by Jumps: Francis Galton and William Bateson and the Mechanism of Evolutionary Change". Genetics. 159 (4): 1383–1392.
- De Vries, Hugo (1922). Willis, J. C. (ed.). Age and Area and the Mutation Theory. Age and Area. A Study in Geographical Distribution and Origin of Species. Cambridge University Press. p. 222.
- Endersby 2007, pp. 202–205.
- De Vries, Hugo (1901–1903). Die mutationstheorie. Vol I and II [The Mutation Theory]. Von Veit, Leipzig. Part 2, 1903
- de Vries, Hugo (January 1919). "Oenothera rubrinervis; A Half Mutant". Botanical Gazette. 67 (1): 1–26. doi:10.1086/332396. JSTOR 2468868.
- Bowler 2003, p. 276.
- De Vries, Hugo (1905). Species and Varieties: Their Origin by Mutation. The Open Court Publishing Company, Chicago.
- Larson 2004, p. 128.
- Provine 2001, pp. 92–100.
- N. Roll-Hansen (1989). "The crucial experiment of Wilhelm Johannsen". Biology and Philosophy. 4 (3): 303–329. doi:10.1007/bf02426630.
- Richmond, M. L. (2006). "The 1909 Darwin celebration. Reexamining evolution in the light of Mendel, mutation, and meiosis". Isis. 97 (3): 447–484. doi:10.1086/508076.
- Bowler 2003, pp. 265–270.
- Johannsen, W. (1903) "Om arvelighed i samfund og i rene linier". Oversigt over det Kongelige Danske Videnskabernes Selskabs Forhandlinger, vol. 3: 247-270 (in Danish). German ed. Erblichkeit in Populationen und in reinen Linien [On inheritance in populations and in pure lines] (1903) Gustav Fischer, Jena. Scanned full text.
- Johannsen, W. L. (1905). Arvelighedslærens elementer [The Elements of Heredity] (in Danish).
- Punnett, Reginald C. (1915). Mimicry in Butterflies. Cambridge University Press.
- Yule, G. Udny (1902). "Mendel's Laws and their probable relations to inter-racial heredity". New Phytologist. 1 (10): 226–227. doi:10.1111/j.1469-8137.1902.tb07336.x.
- Provine 2001, pp. 81–82.
- Nilsson-Ehle, H. (1908). "Einige Ergebnisse von Kreuzungen bei Hafer und Weizen" [Observations on Crosses in Oats and Wheat]. Botaniska Notiser (in German): 257–294.
- Provine 2001, pp. 114–118.
- East, Edward (1910). "A Mendelian Interpretation of Variation that is Apparently Continuous". American Naturalist. 44 (518): 65–82. doi:10.1086/279117. JSTOR 2455657.
- Provine 2001, pp. 118–120.
- Fisher, Ronald A. (1918). "The Correlation Between Relatives on the Supposition of Mendelian Inheritance". Transactions of the Royal Society of Edinburgh. 52 (2): 399–433. doi:10.1017/s0080456800012163.
- Provine 2001, pp. 140–154
- Provine 2001, pp. 109–114.
- Provine 2001, pp. 120–121.
- Muller, Hermann Joseph (1918). "Genetic Variability, Twin Hybrids and Constant Hybrids, in a Case of Balanced Lethal Factors". Genetics. 2 (5): 422–99. PMC 1200446. PMID 17245914.
- Provine 2001, pp. 121–122.
- Bowler 2003, pp. 307–308.
- Levit, Georgy S.; Olsson, Lennart (2006). "'Evolution on Rails' : Mechanisms and Levels of Orthogenesis" (PDF). Annals of the History and Philosophy of Biology (11): 112–113.
- Hubbs, Carl L. (1942). "The Course of Evolution by J. C. Willis. Review". The American Naturalist. 76 (762): 96–101. doi:10.1086/281018.
- Gould, Stephen J. (1982). The uses of heresy; an introduction to Richard Goldschmidt's The Material Basis of Evolution. Yale University Press. pp. xiii–xlii. ISBN 978-0300028232.
- Berg, Lev (1969) . Nomogenesis; or, Evolution Determined by Law. M.I.T. Press. p. 317.
- Willis, J. C. (1923). "The Origin of Species by Large, rather than by Gradual, Change, and by Guppy's Method of Differentiation". Annals of Botany. 37 (148): 605–628. doi:10.1093/oxfordjournals.aob.a089870.
- Beal, J. M. (1941). "The Course of Evolution by J. C. Willis". Botanical Gazette. 102 (3): 638. doi:10.1086/334994.
- Stoltzfus, A. (2014). "In search of mutation-driven evolution". Evolution & Development. 16: 57–59. doi:10.1111/ede.12062.
- Ruse 1996, pp. 412–413.
- Theissen, Guenter (2010). "Homeosis of the angiosperm flower: Studies on three candidate cases of saltational evolution" (PDF). Palaeodiversity. 3 (Supplement): 131–139.
- Kutschera, U.; Niklas, K. J. (2008). "Macroevolution via secondary endosymbiosis: a Neo-Goldschmidtian view of unicellular hopeful monsters and Darwin's primordial intermediate form". Theory in Biosciences. 127 (3): 277–289. doi:10.1007/s12064-008-0046-8. PMID 18581157.
- Judson, Olivia. (2008). The Monster Is Back, and It's Hopeful. The New York Times.
- Chouard, Tanguy (2010). "Evolution: Revenge of the hopeful monster". Nature. 463 (7283): 864–867. doi:10.1038/463864a. PMID 20164895.
- Page, Robert B.; Boley, Meredith A.; Smith, Jeramiah J.; Putta, Srikrishna; Voss, Stephen R. (2010). "Microarray analysis of a salamander hopeful monster reveals transcriptional signatures of paedomorphic brain development". BMC Evolutionary Biology. 10 (1): 199. doi:10.1186/1471-2148-10-199. PMC 2900274. PMID 20584293.
- Wagner, G. P. (1 January 2013). "The Changing Face of Evolutionary Thinking". Genome Biology and Evolution. 5 (10): 2006–2007. doi:10.1093/gbe/evt150. PMC 3814208.
- Takahata, N (2007). "Molecular Clock: An Anti-neo-Darwinian Legacy". Genetics. 176 (1): 1–6. doi:10.1534/genetics.104.75135. PMC 1893057. PMID 17513888.
Unlike neo-Darwinism, which regards mutation as merely raw material and natural selection as the creative power, Nei's mutationism assumes that the most fundamental process for adaptive evolution is the production of functionally more efficient genotypes by mutation (especially birth and death of duplicated genes) and by recombination.
- Nei, Masatoshi (1984). G. S. Mani (ed.). Genetic Polymorphism and Neomutationism. Evolutionary Dynamics of Genetic Diversity. Lecture Notes in Biomathematics. 53. Springer. pp. 214–241. doi:10.1007/978-3-642-51588-0. ISBN 978-3-540-12903-5.
- Nei, Masatoshi (1987). Molecular Evolutionary Genetics. Columbia University Press. ISBN 978-0231063210.
- Nei, Masatoshi (2007). "The new mutation theory of phenotypic evolution". PNAS. 104 (30): 12235–12242. Bibcode:2007PNAS..10412235N. doi:10.1073/pnas.0703349104. PMC 1941456. PMID 17640887.
- Nei, Masatoshi (2005). "Selectionism and Neutralism in Molecular Evolution". Molecular Biology and Evolution. 22 (12): 2318–2342. doi:10.1093/molbev/msi242. PMC 1513187. PMID 16120807.
- Stoltzfus, A (2006). "Mutationism and the Dual Causation of Evolutionary Change". Evol Dev. 8 (3): 304–317. doi:10.1111/j.1525-142X.2006.00101.x. PMID 16686641.
- Nei, Masatoshi (2013). Mutation-Driven Evolution. Oxford University Press. ISBN 978-0199661732.
- David M. McCandlish & Arlin Stoltzfus (2014). "Modeling Evolution Using the Probability of Fixation: History and Implications". Quarterly Review of Biology. 89 (3): 225–252. doi:10.1086/677571. PMID 25195318.
- Wright, S. I. (2014). "Mutationism 2.0: Viewing Evolution through Mutation's Lens". Evolution. 68 (4): 1225–1227. doi:10.1111/evo.12369. PMID 24673244.
- N. Galtier (2013). "Mutation-Driven Evolution". Syst Biol. 63: 113–114. doi:10.1093/sysbio/syt055.
- Kenneth M. Weiss (2013). "Mutation-Driven Evolution". The American Journal of Human Genetics. 93 (6): 999–1000. doi:10.1016/j.ajhg.2013.11.001. PMC 3852927.
- Futuyma, Douglas J. (2015). Serrelli, E.; Gontier, N. (eds.). Can Modern Evolutionary Theory Explain Macroevolution? (PDF). Macroevolution. Springer. pp. 29–85. ISBN 978-3319150444.
- Gould, Stephen J. (1987). "Is a New and General Theory of Evolution Emerging?". Self-Organizing Systems: 113–130. doi:10.1007/978-1-4613-0883-6_7. ISBN 978-1-4612-8227-3.
- Charlesworth, B. (1982). "Hopeful monsters cannot fly". Paleobiology. 8 (4): 469–474. doi:10.1017/s0094837300007223. JSTOR 2400725.
- Templeton, A. (1982). "Why read Goldschmidt?". Paleobiology. 8 (4): 474–481. doi:10.1017/s0094837300007235. JSTOR 2400726.
- Sterelny, K. (2000). "Development, evolution, and adaptation". Phil Sci (Proc). 67: S369–S387. doi:10.1086/392832. JSTOR 188681.
- Minelli, A. (2010) "Evolutionary developmental biology does not offer a significant challenge to the neo-Darwinian paradigm". In: Ayala FJ, Arp R (eds) Contemporary debates in philosophy of biology. Wiley, Chichester, pp 213–226
- Gardner, Andy (2012). "Darwinism, not mutationism, explains the design of organisms" (PDF). Progress in Biophysics and Molecular Biology. 111 (2–3): 97–98. doi:10.1016/j.pbiomolbio.2012.08.012. PMID 23000353.
- Bowler 1989, p. 246.
- Bowler 1989, pp. 280–281.
- Bowler 1989, p. 210.
- Larson 2004, p. 121.
- Larson 2004, pp. 127–129, 157–167.
- Provine 2001, pp. 56–107.
- Mayr, Ernst (2007). What Makes Biology Unique?: Considerations on the Autonomy of a Scientific Discipline. Cambridge University Press. ISBN 978-0521841146.
- Smocovitis, Vassiliki Betty (1996). Unifying Biology: The Evolutionary Synthesis and Evolutionary Biology. Princeton, New Jersey: Princeton University Press. ISBN 978-0-691-03343-3.
- Stoltzfus, Arlin; Cable, Kele (2014). "Mendelian-Mutationism: The Forgotten Evolutionary Synthesis" (PDF). Journal of the History of Biology. 47 (4): 501–546. doi:10.1007/s10739-014-9383-2. PMID 24811736.
- Bateson, William; Saunders, E. R. (1902). "Experimental Studies in the Physiology of Heredity". Royal Society. Reports to the Evolution Committee.
- Stoltzfus, A.; Cable, K. (2014). "Mendelian-Mutationism: The Forgotten Evolutionary Synthesis". J Hist Biol. 47 (4): 501–546. doi:10.1007/s10739-014-9383-2. PMID 24811736.
- Gayon 1988, pp. 289 and passim.
- Hull, D. L. (1985). "Darwinism as an historical entity: A historiographic proposal". In Kohn, D. (ed.). The Darwinian Heritage. Princeton University Press. pp. 773–812. ISBN 978-0691633657.
- Bowler 1989, pp. 276–281.
- Tax, S.; Callender, C., eds. (1960). Evolution After Darwin: The University of Chicago Centennial. University of Chicago Press, Chicago.
- Allen, Garland E. (1968). "Thomas Hunt Morgan and the problem of natural selection". Journal of the History of Biology. 1 (1): 113–139. doi:10.1007/BF00149778.
- Bateman, Richard M; DiMichele, William A. (2002). Generating and Filtering Major Phenotypic Novelties, NeoGoldschmidtian Saltation Revisited. In Cronk QCB, Bateman RM, Hawkins JA, eds. Developmental Genetics and Plant Evolution. London: Taylor and Francis. pp. 109–159.
- Bowler, Peter J. (2003) . Evolution:The History of an Idea (New ed.). University of California Press. ISBN 978-0-520-23693-6.
- Bowler, Peter J. (1989) . Evolution:The History of an Idea (Revised ed.). University of California Press. ISBN 978-0-520-06386-0.
- Bateson, William. (1894). Materials for the Study of Variation: Treated with Especial Regard to Discontinuity in the Origin of Species. Macmillan.
- Endersby, Jim (2007). A Guinea Pig's History of Biology. Harvard University Press. ISBN 978-0-674-02713-8.
- Gayon, J. (1988). Darwinism's Struggle for Survival: Heredity and the Hypothesis of Natural Selection. Cambridge University Press.
- Larson, Edward J. (2004). Evolution: The Remarkable History of a Scientific Theory. Random House. ISBN 9781588365385.
- Nei, Masatoshi. (2013). Mutation-Driven Evolution. Oxford University Press.
- Provine, W. B. (2001). The Origins of Theoretical Population Genetics, with a new afterword. University of Chicago Press, Chicago.
- Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4.
- Smocovitis, Vassiliki Betty (1996). Unifying Biology: The Evolutionary Synthesis and Evolutionary Biology. Princeton, NJ: Princeton University Press. ISBN 978-0-691-03343-3. LCCN 96005605. OCLC 34411399.