The practice was established in 1976 by Michael and Patty Hopkins and is now run by six senior partners. The practice has won many awards for its work and has been shortlisted for the Stirling Prize three times, including in 2011 for the London 2012 Velodrome, in 2006 for Evelina Children's Hospital and in 2001 for Portcullis House and Westminster Underground Station. The founders were awarded the Royal Institute of British Architects Royal Gold Medal in 1994 and Michael Hopkins was awarded the CBE and knighted for services to architecture.
The practice is known for its attention to detail, innovative approach to construction, honest expression of materials and its energy-efficient designs. Its first building outside of the United Kingdom was the headquarters for GEK in Athens in 2003, followed by Tokyo's Shin-Marunouchi Tower in 2007. It has now designed buildings on four continents, with projects completed or under development in the UK, the US, Italy, Greece, Turkey, India, Japan, the UAE and Saudi Arabia.
Current work includes the new Richard A and Susan F Smith Campus Center at Harvard University in Massachusetts, USA, the Peninsula London Hotel,  and the Engineering and Science Library at University of Nottingham, also in the United Kingdom.
- Tokyo Midtown Hibiya, Tokyo, Japan
- St Thomas' Hospital East Wing, London, United Kingdom (2015)
- Bryanston School: The Tom Wheare Music School, Dorset, United Kingdom (2014)
- Brent Civic Centre, London, United Kingdom (2013)
- WWF-UK Headquarters, Living Planet Centre, London, United Kingdom (2013)
- University of East London: Stratford Library, London, United Kingdom (2013)
- St George's Chapel, Great Yarmouth, United Kingdom (2012)
- Maharashtra Cricket Association Stadium, Pune, India (2012)
- University College Hospital Macmillan Cancer Centre, London, United Kingdom (2012)
- London 2012 Velodrome, London, United Kingdom (2011)
- Rice University: South Colleges, Houston, Texas, USA (2010)
- Rice University: Duncan and McMurtry Colleges, Houston, Texas, USA (2010)
- Princeton University: Frick Chemistry Laboratory, New Jersey, USA (2010)
- Norwich Cathedral Hostry, Norwich, United Kingdom (2009)
- Nottingham Trent University: Newton and Arkwright Buildings, Nottingham, United Kingdom (2009)
- Yale University: Kroon Hall, School of Forestry & Environmental Studies, New Haven, Connecticut, USA (2009)
- Dubai International Financial Centre: Gate Village, Dubai, UAE (2008)
- Lawn Tennis Association: National Tennis Centre, Roehampton, United Kingdom (2007)
- Wellcome Trust: Wellcome Collection, London, United Kingdom (2007)
- Evelina Children's Hospital, London, United Kingdom (2006)
- Wellcome Trust: Gibbs Building, London, United Kingdom (2004)
- Norwich Cathedral Refectory, Norwich, United Kingdom (2004)
- Portcullis House, New Parliamentary Building, London, United Kingdom (2001)
- Westminster Underground Station, London, United Kingdom (2001)
- The Forum, Norwich, United Kingdom (2001)
- University of Nottingham: Jubilee Campus, Nottingham, United Kingdom (1999)
- Our Dynamic Earth, Edinburgh, United Kingdom (1999)
- University of Cambridge: Queen's Building, Emmanuel College, Cambridge, United Kingdom (1995)
- Victoria and Albert Museum Masterplan, London, United Kingdom (1993)
- Inland Revenue Centre, Nottingham, United Kingdom (1994)
- Glyndebourne Opera House, Sussex, United Kingdom (1994)
- Bracken House, London, United Kingdom (1992)
- Lord's Cricket Ground: Mound Stand, London, United Kingdom (1987)
- Schlumberger Research Centre, Cambridge, United Kingdom (1982 – 1985)
- Hopkins House, London, United Kingdom (1976)
Westminster Underground Station, London
Shin-Marunouchi Building, Tokyo
Yale University: Kroon Hall, School of Forestry & Environmental Studies, New Haven
- 2015 British Council for Offices: Innovation Award for "WWF-UK's Living Planet Centre"
- 2015 BREEAM Award: Highly Commended for "WWF-UK's Living Planet Centre"
- 2014 Building Magazine: Sustainable Project of the Year for "Brent Civic Centre"
- 2014 British Council for Offices: Corporate Workplace, London Regional Award for "Brent Civic Centre"
- 2013 ArchDaily Building of the Year Award for "London 2012 Velodrome"
- 2012 Design Museum: Architecture Design of the Year Award for "London 2012 Velodrome"
- 2012 BCIA Prime Minister's Better Public Building Award for "UCH Macmillan Cancer Centre"
- 2012 Elle Decoration: British Design Awards, First Place for "London 2012 Velodrome"
- 2011 AJ100 Building of the Year Award for "London 2012 Velodrome"
- 2011 Stirling Prize People's Choice Award for "London 2012 Velodrome"
- 2010 AIA COTE (Committee on the Environment) Top Ten Award for "Kroon Hall"
- 2010 AJ100 Building of the Year Award for "Kroon Hall"
- 2009 British Council for Offices: Best Commercial Workplace Award for "Butterfield Park Innovation Centre"
- 2008 British Council for Offices: Best of the Best Award for "Lawn Tennis Association: National Tennis Centre"
- 2008 Building Magazine Sustainable Architect of the Year Award
- 2006 Building Better Healthcare Awards: Best NHS Hospital Design for "Evelina Children's Hospital"
- 2005 Time Out Magazine: London Eating & Drinking Awards, Best in category for "Inn the Park"
- 2003 Royal Fine Art Commission Trust: Aggiornamento Award for "Manchester Art Gallery"
- 2000 Royal Fine Art Commission Trust: Millennium Building of the Year Award for "Westminster Underground Station"
Former Hopkins staff who have gone on to make their mark elsewhere in architecture include Chris Wilkinson and Bill Dunster. Former directors John Pringle and Ian Sharratt went on to set up their own practice Pringle Richards Sharratt.
Buildings by Hopkins appear in two James Bond films. The interior of the IBM Building at Bedfont Lakes serves as the location for Elliot Carver's media party in Hamburg in Tomorrow Never Dies. In the following film, The World Is Not Enough, Portcullis House makes a fleeting appearance in the boat chase down the Thames.
On 22 October 2006 the practice's Westminster Underground Station was closed for the day to allow filming for Harry Potter and the Order of the Phoenix to take place for a scene where Harry takes the tube with Arthur Weasley to go to a disciplinary hearing at the Ministry of Magic.
As one of the main venues during the 2012 Summer Olympics in London, the interior and exterior of the 2012 London Velodrome featured prominently during track cycling events on many major networks throughout the world.
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- BBC News: Harry Potter rides on London Tube 22 October 2006
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