Hops and cannabinoids
Research has shown that Humulus lupulus (the plant that makes hops) and Cannabis sativa (also called hemp and marijuana) are closely related and it may be possible to create novel strains of hops that express valuable chemicals similar to commercial hemp.[a] Both hops and cannabis contain terpenes and terpenoids; tetrahydrocannabinol (THC) is a terpenoid. Hops lack the enzyme that could convert cannabigerolic acid into THC or CBD, but it could be inserted using genetic engineering as was reported in 2019 for yeast.
Humulus kriya hoax
Humulus kriya was a strain of that was claimed by Moses Sunith Prasad Joseph, aka Bomi Boban Joseph, to have commercially-valuable levels of cannabidiol (CBD). In 2019, High Times and other cannabis industry publications described it as a hoax or con job.
- See subsection titled "The incredibly parallel histories of cannabis and its closest relative, humulus (hop)" in Small (2016)
- Small 2016.
- Andre, Christelle M.; Hausman, Jean-Francois; Guerriero, Gea (2016), "Cannabis sativa: The Plant of the Thousand and One Molecules", Frontiers in Plant Science, 7 (19), PMC 4740396, PMID 26870049
- Harbison, Martha (November 15, 2012), "BeerSci: What's The Connection Between Hops And Marijuana? Because they sure look and smell alike.", Popular Science
- Kaplan, Josh (July 12, 2018). "Does CBD Only Come From Cannabis and Hemp?". Leafly.
- Bushwick, Sophie (February 27, 2019). "Rising High: GM Yeast Generates Known and Novel Marijuana Compounds – Engineered microorganisms churn out THC, CBD and rarer, less-understood cannabis cousins". Scientific American.
- Luo, Xiaozhou; Reiter, Michael A.; d’Espaux, Leo; Wong, Jeff; Denby, Charles M.; Lechner, Anna; Zhang, unfeng; Grzybowski, Adrian T.; Harth, Simon; Lin, Weiyin; Lee, Hyunsu; Yu, Changhua; Shin, John; Deng, Kai; Benites, Veronica T.; Wang, George; Baidoo, Edward E. K.; Chen, Yan; Dev, Ishaan; Petzold, Christopher J.; Keasling, Jay D. (February 27, 2019), "Complete biosynthesis of cannabinoids and their unnatural analogues in yeast", Nature, 567: 123–126, doi:10.1038/s41586-019-0978-9CS1 maint: Uses authors parameter (link)
- Herrington, A.J. (February 26, 2019). "Researcher Who Claimed CBD In Hops Revealed As Convicted Con Artist". High Times.
- Dorfman, Brandon (February 22, 2019). "A PotNetwork News investigative report: Bomi Joseph's "hops-derived" CBD was a world-changing cannabis alternative fought over by Isodiol and Medical Marijuana Inc. But he lied about his discovery — and his identity". PotNetwork.
- Small, Ernest (November 2016), "Prehuman and early history of Cannabis sativa", Cannabis: A Complete Guide, CRC Press, ISBN 978-1498761635, OCLC 971400059
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