From the first partition of Poland in 1772 until 1918, the town was part of the Austrian monarchy (Austria side after the compromise of 1867), head of the district with the same name, one of the 78 Bezirkshauptmannschaften in Austrian Galicia province (Crown land) in 1900. The fate of this province was then disputed between Poland and Ukraine, until the Peace of Riga in 1921.
During World War II the Jewish population of Horodenka, comprising about half of the town's population, were shot and killed in a mass grave by the Nazis. About a dozen Jews survived and formed a partisan combat unit which fought against the Nazis and hid in the forests.. There is a synagogue in Salford, England named in honour of this community.
Alexander Granach (Jessaja Szajko Gronish), leading stage and film actor in Weimar Germany, died at 52 while establishing himself in Hollywood and on Broadway. Author of autobiography, There Goes an Actor [new edition: From the Shtetl to the Stage: the Odyssey of a Wandering Actor].