"How We Do" achieved commercial success worldwide. The track peaked within the top 10 in multiple countries, including the United Kingdom, Ireland, Netherlands, Switzerland, Germany and New Zealand. The single was commercially successful in the United States, peaking at #4 on the Billboard Hot 100 and remaining on the chart for 28 consecutive weeks. "How We Do" marked Game's first top-ten single on the chart as a lead artist and also marked 50 Cent's fifth overall top-ten single.
This song is considered to be one of Game's most well-known and recognizable songs.
The song was a hit at Urban and Rhythmic radio stations in America, and was a success on American mainstreampop music radio stations. In the U.S., the song debuted at #65 and peaked at #4 on the Billboard Hot 100 in early 2005, making it The Game's first top-five hit. The song was also certified Gold by the RIAA.
The song fell down the charts relatively quickly for a top-ten hit. This was likely due to an overabundance of Shady/Aftermath/G-Unit-related singles all competing for airtime during this time period, as Eminem and G-Unit members 50 Cent, Lloyd Banks, Young Buck, and Game all had songs on the chart during the months of late 2004 and early 2005. However, despite its fast fall out of the top twenty, the song managed to hang on in the lower rungs of the top 40 for months, in spite of, or possibly because of, The Game's follow up, "Hate It or Love It" becoming even bigger on pop radio only a few weeks after "How We Do" had peaked. Dr. Dre had produced "How We Do" during his time in N.W.A