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24 November 1893|
Fuzhou, Fujian, China
|Died||8 August 1959
Boston, Massachusetts, United States
|Nationality||Republic of China|
Hsien Wu (simplified Chinese: 吴宪; traditional Chinese: 吳憲; pinyin: Wú Xiàn; 24 November 1893 – 8 August 1959) was a Chinese protein scientist. He was the first to propose that protein denaturation was a purely conformational change, i.e., corresponded to protein unfolding and not to some chemical alteration of the protein. This crucial idea was popularized later by Linus Pauling and Alfred Mirsky.
Wu was born in Fuzhou, Fujian, China. He studied at MIT (undergraduate), and then trained at Harvard University (graduate) under Otto Folin, developing the first assay for blood sugar (Folin-Wu method). Wu then returned to China to a position at Peking Union Medical College, becoming head of the biochemistry department in 1924 at age 30.
Wu left China in 1947 to reside in the United States.
- Wu, H (1931). "Studies on Denaturation of Proteins. XIII. A Theory of Denaturation". Chinese Journal of Physiology. 5: 321–344. Preliminary reports were presented before the XIIIth International Congress of Physiology at Boston (19–24 August 1929) and in the October 1929 issue of the American Journal of Physiology.
- Mirsky, AE; Pauling L (1936). "On the Structure of Native, Denatured, and Coagulated Proteins". Proceedings of the National Academy of Sciences USA. 22 (7): 439–447. doi:10.1073/pnas.22.7.439.
- Edsall, JT (1995). "Hsien Wu and the First Theory of Protein Denaturation". Advances in Protein Chemistry. Advances in Protein Chemistry. 46: 1–5. doi:10.1016/S0065-3233(08)60329-0. ISBN 978-0-12-034246-4.
- Bishop, Charles (1 February 1982). "Hsien Wu (1893-1959): A Biographical Sketch". Clinical Chemistry. 28 (2): 378–80. PMID 7035008.
- Wu, DY (1959). Hsien Wu 1893-1959: In Loving Memory. Boston: published privately.
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