HslU—HslV peptidase

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HslU—HslV peptidase
Heat shock peptidase dodekamer, E.Coli
EC number3.4.25.2
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

HslU—HslV peptidase (EC, HslUV, HslV-HslU, HslV peptidase, ATP-dependent HslV-HslU proteinase, caseinolytic protease X, caseinolytic proteinase X, ClpXP ATP-dependent protease, ClpXP protease, ClpXP serine proteinase, Escherichia coli ClpXP serine proteinase, HslUV protease, HslUV proteinase, HslVU protease, HslVU proteinase, protease HslVU, proteinase HslUV) is an enzyme.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

ATP-dependent cleavage of peptide bonds with broad specificity.

This enzyme belongs to the peptidase family T1.


  1. ^ Wang J, Rho SH, Park HH, Eom SH (July 2005). "Correction of X-ray intensities from an HslV-HslU co-crystal containing lattice-translocation defects". Acta Crystallographica Section D. 61 (Pt 7): 932–41. doi:10.1107/s0907444905009546. PMID 15983416.
  2. ^ Nishii W, Takahashi K (October 2003). "Determination of the cleavage sites in SulA, a cell division inhibitor, by the ATP-dependent HslVU protease from Escherichia coli". FEBS Letters. 553 (3): 351–4. doi:10.1016/s0014-5793(03)01044-5. PMID 14572649.
  3. ^ Ramachandran R, Hartmann C, Song HK, Huber R, Bochtler M (May 2002). "Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY)". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7396–401. doi:10.1073/pnas.102188799. PMC 124242. PMID 12032294.
  4. ^ Yoo SJ, Seol JH, Shin DH, Rohrwild M, Kang MS, Tanaka K, Goldberg AL, Chung CH (June 1996). "Purification and characterization of the heat shock proteins HslV and HslU that form a new ATP-dependent protease in Escherichia coli". The Journal of Biological Chemistry. 271 (24): 14035–40. doi:10.1074/jbc.271.24.14035. PMID 8662828.
  5. ^ Yoo SJ, Seol JH, Seong IS, Kang MS, Chung CH (September 1997). "ATP binding, but not its hydrolysis, is required for assembly and proteolytic activity of the HslVU protease in Escherichia coli". Biochemical and Biophysical Research Communications. 238 (2): 581–5. doi:10.1006/bbrc.1997.7341. PMID 9299555.
  6. ^ Kanemori M, Nishihara K, Yanagi H, Yura T (December 1997). "Synergistic roles of HslVU and other ATP-dependent proteases in controlling in vivo turnover of sigma32 and abnormal proteins in Escherichia coli". Journal of Bacteriology. 179 (23): 7219–25. PMC 179669. PMID 9393683.
  7. ^ Burton RE, Baker TA, Sauer RT (March 2005). "Nucleotide-dependent substrate recognition by the AAA+ HslUV protease". Nature Structural & Molecular Biology. 12 (3): 245–51. doi:10.1038/nsmb898. PMID 15696175.

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