Hsp90 cis-regulatory element

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Hsp90 cis-regulatory element
Predicted secondary structure and sequence conservation of Hsp90_CRE
Symbol Hsp90_CRE
Rfam RF00433
Other data
RNA type Cis-reg; thermoregulator
Domain(s) Eukaryota
SO 0000233

The Hsp90 cis regulatory element is an RNA element (RNA thermometer) found in the 5' UTR of the Drosophila hsp90 mRNA. It is required for increased translational efficiency during the heat shock response.

The hsp90 gene product is involved in the Drosophila heat shock response. Translation of the hsp90 mRNA is very inefficient under normal growth temperatures, when heat shock occurs translation becomes more efficient. This is mediated though this regulatory element.[1]

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  1. ^ Ahmed, R; Duncan RF (2004). "Translational regulation of Hsp90 mRNA. AUG-proximal 5'-untranslated region elements essential for preferential heat shock translation". J Biol Chem. 279 (48): 49919–49930. doi:10.1074/jbc.M404681200. PMID 15347681. 

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