HtrA2 peptidase
| HtrA2 peptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.108 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
HtrA2 peptidase (EC 3.4.21.108, high temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, serine proteinase OMI, OMI/HtrA2 protease, HtrA2/Omi, Omi/HtrA2) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met.
This enzyme is upregulated in mammalian cells in response to stress induced by heat shock and tunicamycin treatment.
References
- ^ Srinivasula, S.M.; Gupta, S.; Datta, P.; Zhang, Z.; Hegde, R.; Cheong, N.; Fernandes-Alnemri, T.; Alnemri, E.S. (2003). "Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2". J. Biol. Chem. 278: 31469–31472. doi:10.1074/jbc.C300240200. PMID 12835328.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Savopoulos, J.W.; Carter, P.S.; Turconi, S.; Pettman, G.R.; Karran, E.H.; Gray, C.W.; Ward, R.V.; Jenkins, O.; Creasy, C.L. (2000). "Expression, purification, and functional analysis of the human serine protease HtrA2". Protein. Expr. Purif. 19: 227–234. doi:10.1006/prep.2000.1240. PMID 10873535.
- ^ Martins, L.M.; Turk, B.E.; Cowling, V.; Borg, A.; Jarrell, E.T.; Cantley, L.C.; Downward, J. (2003). "Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi". J. Biol. Chem. 278 (49): 49417–49427. doi:10.1074/jbc.M308659200. PMID 14512424.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Gray, C.W.; Ward, R.V.; Karran, E.; Turconi, S.; Rowles, A.; Viglienghi, D.; Southan, C.; Barton, A.; Fantom, K.G.; West, A.; Savopoulos, J.; Hassan, N.J.; Clinkenbeard, H.; Hanning, C.; Amegadzie, B.; Davis, J.B.; Dingwall, C.; Livi, G.P.; Creasy, C.L. (2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". Eur. J. Biochem. 267: 5699–5710. doi:10.1046/j.1432-1327.2000.01589.x. PMID 10971580.
- ^ Li, W.; Srinivasula, S.M.; Chai, J.; Li, P.; Wu, J.W.; Zhang, Z.; Alnemri, E.S.; Shi, Y. (2002). "Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi". Nat. Struct. Biol. 9 (6): 436–441. doi:10.1038/nsb795. PMID 11967569.
External links
- HtrA2+peptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)