He had two children with his first wife, American actress Faith Domergue. The couple were married in Buenos Aires, at the San America Hotel, on June 16, 1947. The couple had a tumultuous relationship but it finally brought happiness when their first child, Diana Maria, was born on July 19, 1948 and the second child, John Anthony, was born on May 14, 1950. The couple separated in 1957 and divorced on January 28, 1958.
In his later years, Fregonese directed films in Europe.