||This article or section contains close paraphrasing of one or more non-free copyrighted sources. Ideas in this article should be expressed in an original manner. (September 2014)|
|This article or section may have been copied and pasted from Wolkoff, P; Skov, P; Franck, C; Petersen, LN (December 2003). "Eye irritation and environmental factors in the office environment—hypotheses, causes and a physiological model". ( ), possibly in violation of Wikipedia's copyright policy. Please remedy this by editing this article to remove any non-free copyrighted content and attributing free content correctly, or flagging the content for deletion. Please be sure that the supposed source of the copyright violation is not itself a Wikipedia mirror. (September 2014)|
|The human eye|
1. vitreous body 2. ora serrata 3. ciliary muscle 4. ciliary zonules 5. Schlemm's canal 6. pupil 7. anterior chamber 8. cornea 9. iris 10. lens cortex 11. lens nucleus 12. ciliary process 13. conjunctiva 14. inferior oblique muscle 15. inferior rectus muscle 16. medial rectus muscle 17. retinal arteries and veins 18. optic disc 19. dura mater 20. central retinal artery 21. central retinal vein 22. optic nerve 23. vorticose vein 24. bulbar sheath 25. macula 26. fovea 27. sclera 28. choroid 29. superior rectus muscle 30. retina
The human eye is an organ that reacts to light and has several purposes. As a sense organ, the mammalian eye allows vision. Rod and cone cells in the retina allow conscious light perception and vision including color differentiation and the perception of depth. The human eye can distinguish about 10 million colors.
Similar to the eyes of other mammals, the human eye's non-image-forming photosensitive ganglion cells in the retina receive light signals which affect adjustment of the size of the pupil, regulation and suppression of the hormone melatonin and entrainment of the body clock.
- 1 Structure
- 2 Vision
- 3 Eye movement
- 4 Near response
- 5 Clinical significance
- 6 Additional images
- 7 See also
- 8 References
- 9 External links
The eye is not shaped like a perfect sphere, rather it is a fused two-piece unit. The smaller frontal unit, transparent and more curved, called the cornea is linked to the larger white unit called the sclera. The corneal segment is typically about 8 mm (0.3 in) in radius. The sclerotic chamber constitutes the remaining five-sixths; its radius is typically about 12 mm. The cornea and sclera are connected by a ring called the limbus. The iris is the colored circular structure concentrically surrounding the center of the eye, the pupil, which appears to be black. A device known as an ophthalmoscope is used to see inside the eye.
Light enters the eye through the cornea, then the pupil and then through the lens controlled by ciliary muscles. Light falling on the light-sensitive cells of the retina is converted into electrical signals that are carried to the brain by the optic nerves.
The dimensions differ among adults by only one or two millimetres; it is remarkably consistent across different ethnicities. The vertical measure, generally less than the horizontal distance, is about 24 mm among adults, at birth about 16–17 millimetres (about 0.65 inch). The transverse size of a human adult eye is approximately 24.2 mm and the sagittal size is 23.7 mm with no significant difference between sexes and age groups. Strong correlation was found between the transverse diameter and the width of the orbit (r = 0.88).
The eyeball grows rapidly, increasing to 22.5–23 mm (approx. 0.89 in) by three years of age. By age 13, the eye attains its full size. The typical adult eye has an anterior to posterior diameter of 24 millimetres, a volume of six cubic centimetres (0.4 cu. in.), and a mass of 7.5 grams (weight of 0.25 oz.).
The eye is made up of three coats, enclosing three transparent structures. The outermost layer, known as the fibrous tunic, is composed of the cornea and sclera. The middle layer, known as the vascular tunic or uvea, consists of the choroid, ciliary body, and iris. The innermost is the retina, which gets its circulation from the vessels of the choroid as well as the retinal vessels, which can be seen in an ophthalmoscope.
Within these coats are the aqueous humour, the vitreous body, and the flexible lens. The aqueous humour is a clear fluid that is contained in two areas: the anterior chamber between the cornea and the iris, and the posterior chamber between the iris and the lens. The lens is suspended to the ciliary body by the suspensory ligament (Zonule of Zinn), made up of fine transparent fibers. The vitreous body is a clear jelly that is much larger than the aqueous humour present behind the lens, and the rest is bordered by the sclera, zonule, and lens. They are connected via the pupil.
Field of view
The approximate field of view of an individual human eye (measured from the fixation point, i.e., the point at which one's gaze is directed) is 60° superior (up), 60° nasal (towards the nose), 70-75° inferior (down), and 100-110° temporal (away from the nose and towards the temple). For both eyes the combined visual field is 130-135° vertical and 200° horizontal. When viewed at large angles, the iris and pupil appear to be rotated toward the viewer. As a result the pupil may still be visible at angles greater than 90°.
The retina has a static contrast ratio of around 100 000:1 (about 6.5 f-stops). As soon as the eye moves (saccades) it re-adjusts its exposure both chemically and mechanically by adjusting the iris which regulates the size of the pupil. Initial dark adaptation takes place in approximately four seconds of profound, uninterrupted darkness; full adaptation through adjustments in retinal chemistry (the Purkinje effect) is mostly complete in thirty minutes. The process is nonlinear and multifaceted, so an interruption by light merely starts the adaptation process over again. Full adaptation is dependent on good blood flow; thus dark adaptation may be hampered by poor circulation, and vasoconstrictors like tobacco.
The human eye can detect a luminance range of 1014, or one hundred trillion (100,000,000,000,000) (about 46.5 f-stops), from 10−6 cd/m2, or one millionth (0.000001) of a candela per square meter to 108 cd/m2 or one hundred million (100,000,000) candelas per square meter. This range does not include looking at the midday sun (109 cd/m2) or lightning discharge.
At the low end of the range is the absolute threshold of vision for a steady light across a wide field of view, about 10−6 cd/m2 (0.000001 candela per square meter). The upper end of the range is given in terms of normal visual performance as 108 cd/m2 (100,000,000 or one hundred million candelas per square meter).
The eye includes a lens similar to lenses found in optical instruments such as cameras and the same principles can be applied. The pupil of the human eye is its aperture; the iris is the diaphragm that serves as the aperture stop. Refraction in the cornea causes the effective aperture (the entrance pupil) to differ slightly from the physical pupil diameter. The entrance pupil is typically about 4 mm in diameter, although it can range from 2 mm (f/8.3) in a brightly lit place to 8 mm (f/2.1) in the dark. The latter value decreases slowly with age; older people's eyes sometimes dilate to not more than 5-6mm.
The visual system in the human brain is too slow to process information if images are slipping across the retina at more than a few degrees per second. Thus, to be able to see while moving, the brain must compensate for the motion of the head by turning the eyes. Frontal-eyed animals have a small area of the retina with very high visual acuity, the fovea centralis. It covers about 2 degrees of visual angle in people. To get a clear view of the world, the brain must turn the eyes so that the image of the object of regard falls on the fovea. Any failure to make eye movements correctly can lead to serious visual disabilities.
Having two eyes allows the brain to determine the depth and distance of an object. Both eyes must point accurately enough that the object of regard falls on corresponding points of the two retinas; otherwise, double vision occurs. The movements of different body parts are controlled by striated muscles acting around joints. The movements of the eye are no exception, but they have special advantages not shared by skeletal muscles and joints, and so are considerably different.[clarification needed]
Each eye has six muscles that control its movements: the lateral rectus, the medial rectus, the inferior rectus, the superior rectus, the inferior oblique, and the superior oblique. When the muscles exert different tensions, a torque is exerted on the globe that causes it to turn, in almost pure rotation, with only about one millimeter of translation. Thus, the eye can be considered as undergoing rotations about a single point in the center of the eye.
Rapid eye movement
Rapid eye movement, REM, typically refers to the sleep stage during which the most vivid dreams occur. During this stage, the eyes move rapidly. It is not in itself a unique form of eye movement.
Saccades are quick, simultaneous movements of both eyes in the same direction controlled by the frontal lobe of the brain. Some irregular drifts, movements, smaller than a saccade and larger than a microsaccade, subtend up to one tenth of a degree
Even when looking intently at a single spot, the eyes drift around. This ensures that individual photosensitive cells are continually stimulated in different degrees. Without changing input, these cells would otherwise stop generating output. Microsaccades move the eye no more than a total of 0.2° in adult humans.
The vestibulo-ocular reflex is a reflex eye movement that stabilizes images on the retina during head movement by producing an eye movement in the direction opposite to head movement, thus preserving the image on the center of the visual field. For example, when the head moves to the right, the eyes move to the left, and vice versa.
Smooth pursuit movement
Eyes can also follow a moving object around. This tracking is less accurate than the vestibulo-ocular reflex, as it requires the brain to process incoming visual information and supply feedback. Following an object moving at constant speed is relatively easy, though the eyes will often make saccadic jerks to keep up. The smooth pursuit movement can move the eye at up to 100°/s in adult humans.
It is more difficult to visually estimate speed in low light conditions or while moving, unless there is another point of reference for determining speed.
The optokinetic reflex is a combination of a saccade and smooth pursuit movement. When, for example, looking out of the window at a moving train, the eyes can focus on a 'moving' train for a short moment (through smooth pursuit), until the train moves out of the field of vision. At this point, the optokinetic reflex kicks in, and moves the eye back to the point where it first saw the train (through a saccade).
The adjustment to close-range vision involves three processes to focus an image on the retina.
When a creature with binocular vision looks at an object, the eyes must rotate around a vertical axis so that the projection of the image is in the centre of the retina in both eyes. To look at an object close by, the eyes rotate 'towards each other' (convergence), while for an object farther away they rotate 'away from each other' (divergence). Exaggerated convergence is called cross eyed viewing (focusing on one's nose for example).
Lenses cannot refract light rays at their edges as well as they can closer to the center. The image produced by any lens is therefore somewhat blurry around the edges (spherical aberration). It can be minimized by screening out peripheral light rays and looking only at the better-focused center. In the eye, the pupil serves this purpose by constricting while the eye is focused on nearby objects. In this way the pupil has a dual purpose: to adjust the eye to variations in brightness and to reduce spherical aberration.
Accommodation of the lens
Accommodation by changing the curvature of the lens is carried out by the ciliary muscles surrounding the lens. They narrow the diameter of the ciliary body, relax the fibers of the suspensory ligament, and allow the lens to relax into a more convex shape. A more convex lens refracts light more strongly and focuses divergent light rays onto the retina allowing for closer objects to be brought into focus.
Eye care professionals
The human eye contains enough complexity to warrant specialized attention and care beyond the duties of a general practitioner. These specialists, or eye care professionals, serve different functions in different countries. Each eye care professional can typically be categorized into one or a multiplicity (i.e. an ophthalmologist can perform surgery; and in some instances prescribe lenses, which is a duty often performed by optometrists) of duties of the following types of professionals:
Eye irritation has been defined as “the magnitude of any stinging, scratching, burning, or other irritating sensation from the eye”. It is a common problem experienced by people of all ages. Related eye symptoms and signs of irritation are discomfort, dryness, excess tearing, itching, grating, sandy sensation, ocular fatigue, pain, scratchiness, soreness, redness, swollen eyelids, and tiredness, etc. These eye symptoms are reported with intensities from severe to mild. It has been suggested that these eye symptoms are related to different causal mechanisms.
Several suspected causal factors in our environment have been studied so far. One hypothesis is that indoor air pollution may cause eye and airway irritation. Eye irritation depends somewhat on destabilization of the outer-eye tear film, in which the formation of dry spots result in such ocular discomfort as dryness. Occupational factors are also likely to influence the perception of eye irritation. Some of these are lighting (glare and poor contrast), gaze position, a limited number of breaks, and a constant function of accommodation, musculoskeletal burden, and impairment of the visual nervous system. Another factor that may be related is work stress. In addition, psychological factors have been found in multivariate analyses to be associated with an increase in eye irritation among VDU users. Other risk factors, such as chemical toxins/irritants (e.g. amines, formaldehyde, acetaldehyde, acrolein, N-decane, VOCs, ozone, pesticides and preservatives, allergens, etc.) might cause eye irritation as well.
Certain volatile organic compounds that are both chemically reactive and airway irritants may cause eye irritation. Personal factors (e.g. use of contact lenses, eye make-up, and certain medications) may also affect destabilization of the tear film and possibly result in more eye symptoms. Nevertheless, if airborne particles alone should destabilize the tear film and cause eye irritation, their content of surface-active compounds must be high. An integrated physiological risk model with blink frequency, destabilization, and break-up of the eye tear film as inseparable phenomena may explain eye irritation among office workers in terms of occupational, climate, and eye-related physiological risk factors.
There are two major measures of eye irritation. One is blink frequency which can be observed by human behavior. The other measures are break up time, tear flow, hyperemia (redness, swelling), tear fluid cytology, and epithelial damage (vital stains) etc., which are human beings’ physiological reactions. Blink frequency is defined as the number of blinks per minute and it is associated with eye irritation. Blink frequencies are individual with mean frequencies of < 2-3 to 20-30 blinks/minute, and they depend on environmental factors including the use of contact lenses. Dehydration, mental activities, work conditions, room temperature, relative humidity, and illumination all influence blink frequency. Break-up time (BUT) is another major measure of eye irritation and tear film stability. It is defined as the time interval (in seconds) between blinking and rupture. BUT is considered to reflect the stability of the tear film as well. In normal persons, the break-up time exceeds the interval between blinks, and, therefore, the tear film is maintained. Studies have shown that blink frequency is correlated negatively with break-up time. This phenomenon indicates that perceived eye irritation is associated with an increase in blink frequency since the cornea and conjunctiva both have sensitive nerve endings that belong to the first trigeminal branch. Other evaluating methods, such as hyperemia, cytology etc. have increasingly been used to assess eye irritation.
There are other factors that are related to eye irritation as well. Three major factors that influence the most are indoor air pollution, contact lenses and gender differences. Field studies have found that the prevalence of objective eye signs is often significantly altered among office workers in comparisons with random samples of the general population. These research results might indicate that indoor air pollution has played an important role in causing eye irritation. There are more and more people wearing contact lens now and dry eyes appear to be the most common complaint among contact lens wearers. Although both contact lens wearers and spectacle wearers experience similar eye irritation symptoms, dryness, redness, and grittiness have been reported far more frequently among contact lens wearers and with greater severity than among spectacle wearers. Studies have shown that incidence of dry eyes increases with age. especially among women. Tear film stability (e.g. break-up time) is significantly lower among women than among men. In addition, women have a higher blink frequency while reading. Several factors may contribute to gender differences. One is the use of eye make-up. Another reason could be that the women in the reported studies have done more VDU work than the men, including lower grade work. A third often-quoted explanation is related to the age-dependent decrease of tear secretion, particularly among women after 40 years of age.
In a study conducted by UCLA, the frequency of reported symptoms in industrial buildings was investigated. The study's results were that eye irritation was the most frequent symptom in industrial building spaces, at 81%. Modern office work with use of office equipment has raised concerns about possible adverse health effects. Since the 1970s, reports have linked mucosal, skin, and general symptoms to work with self-copying paper. Emission of various particulate and volatile substances has been suggested as specific causes. These symptoms have been related to Sick building syndrome (SBS), which involves symptoms such as irritation to the eyes, skin, and upper airways, headache and fatigue.
Many of the symptoms described in SBS and multiple chemical sensitivity (MCS) resemble the symptoms known to be elicited by airborne irritant chemicals. A repeated measurement design was employed in the study of acute symptoms of eye and respiratory tract irritation resulting from occupational exposure to sodium borate dusts. The symptom assessment of the 79 exposed and 27 unexposed subjects comprised interviews before the shift began and then at regular hourly intervals for the next six hours of the shift, four days in a row. Exposures were monitored concurrently with a personal real time aerosol monitor. Two different exposure profiles, a daily average and short term (15 minute) average, were used in the analysis. Exposure-response relations were evaluated by linking incidence rates for each symptom with categories of exposure.
Acute incidence rates for nasal, eye, and throat irritation, and coughing and breathlessness were found to be associated with increased exposure levels of both exposure indices. Steeper exposure-response slopes were seen when short term exposure concentrations were used. Results from multivariate logistic regression analysis suggest that current smokers tended to be less sensitive to the exposure to airborne sodium borate dust.
Several actions can be taken to prevent eye irritation—
- trying to maintain normal blinking by avoiding room temperatures that are too high; avoiding relative humidities that are too high or too low, because they reduce blink frequency or may increase water evaporation
- trying to maintain an intact tear film by the following actions. 1) blinking and short breaks may be beneficial for VDU users. Increase these two actions might help maintain the tear film. 2) downward gazing is recommended to reduce the ocular surface area and water evaporation. 3) the distance between the VDU and keyboard should be kept as short as possible to minimize evaporation from the ocular surface area by a low direction of the gaze. And 4) blink training can be beneficial.
As the eye ages, certain changes occur that can be attributed solely to the aging process. Most of these anatomic and physiologic processes follow a gradual decline. With aging, the quality of vision worsens due to reasons independent of diseases of the aging eye. While there are many changes of significance in the non-diseased eye, the most functionally important changes seem to be a reduction in pupil size and the loss of accommodation or focusing capability (presbyopia). The area of the pupil governs the amount of light that can reach the retina. The extent to which the pupil dilates decreases with age, leading to a substantial decrease in light received at the retina. In comparison to younger people, it is as though older persons are constantly wearing medium-density sunglasses. Therefore, for any detailed visually guided tasks on which performance varies with illumination, older persons require extra lighting. Certain ocular diseases can come from sexually transmitted diseases such as herpes and genital warts. If contact between the eye and area of infection occurs, the STD can be transmitted to the eye.
With aging, a prominent white ring develops in the periphery of the cornea called arcus senilis. Aging causes laxity, downward shift of eyelid tissues and atrophy of the orbital fat. These changes contribute to the etiology of several eyelid disorders such as ectropion, entropion, dermatochalasis, and ptosis. The vitreous gel undergoes liquefaction (posterior vitreous detachment or PVD) and its opacities — visible as floaters — gradually increase in number.
Various eye care professionals, including ophthalmologists, optometrists, and opticians, are involved in the treatment and management of ocular and vision disorders. A Snellen chart is one type of eye chart used to measure visual acuity. At the conclusion of a complete eye examination, the eye doctor might provide the patient with an eyeglass prescription for corrective lenses. Some disorders of the eyes for which corrective lenses are prescribed include myopia (near-sightedness) which affects about one-third of the human population, hyperopia (far-sightedness) which affects about one quarter of the population, astigmatism, and presbyopia (the loss of focusing range during aging).
Macular degeneration is especially prevalent in the U.S. and affects roughly 1.75 million Americans each year. Having lower levels of lutein and zeaxanthin within the macula may be associated with an increase in the risk of age-related macular degeneration,. Lutein and zeaxanthin act as antioxidants that protect the retina and macula from oxidative damage from high-energy light waves. As the light waves enter the eye they excite electrons that can cause harm to the cells in the eye, but before they can cause oxidative damage that may lead to macular degeneration or cataracts lutein and zeaxanthin bind to the electron free radical and are reduced rendering the electron safe. There are many ways to ensure a diet rich in lutein and zeaxanthin, the best of which is to eat dark green vegetables including kale, spinach, broccoli and turnip greens. Nutrition is an important aspect of the ability to achieve and maintain proper eye health. Lutein and zeaxanthin are two major carotenoids, found in the macula of the eye, that are being researched to identify their role in the pathogenesis of eye disorders such as age-related macular degeneration and cataracts.
- Asthenopia (eye strain)
- Eye color
- Hyaloid canal
- Spectral sensitivity
- Iris recognition
- Knobloch syndrome
- Lacrimal caruncle
- Judd, Deane B.; Wyszecki, Günter (1975). Color in Business, Science and Industry. Wiley Series in Pure and Applied Optics (third ed.). New York: Wiley-Interscience. p. 388. ISBN 0-471-45212-2.
- Zimmer, Carl (February 2012). "Our Strange, Important, Subconscious Light Detectors". Discover Magazine. Retrieved 2012-05-05.
- "Variations in eyeball diameters of the healthy adults.".
- Cunningham, edited by Paul Riordan-Eva, Emmett T. Vaughan & Asbury's General Ophthalmology. (18th ed.). New York: McGraw-Hill Medical. ISBN 978-0-07-163420-5.
- "eye, human."Encyclopædia Britannica from Encyclopædia Britannica Ultimate Reference Suite 2009
- Savino, Peter J.; Danesh-Meyer, Helen V. (1 May 2012). Color Atlas and Synopsis of Clinical Ophthalmology -- Wills Eye Institute -- Neuro-Ophthalmology. Lippincott Williams & Wilkins. p. 12. ISBN 978-1-60913-266-8. Retrieved 9 November 2014.
- Ryan, Stephen J.; Schachat, Andrew P.; Wilkinson, Charles P.; David R. Hinton; SriniVas R. Sadda; Peter Wiedemann (1 November 2012). Retina. Elsevier Health Sciences. p. 342. ISBN 1-4557-3780-1. Retrieved 9 November 2014.
- Trattler, William B.; Kaiser, Peter K.; Friedman, Neil J. (5 January 2012). Review of Ophthalmology: Expert Consult - Online and Print. Elsevier Health Sciences. p. 255. ISBN 1-4557-3773-9. Retrieved 9 November 2014.
- Dagnelie, Gislin (21 February 2011). Visual Prosthetics: Physiology, Bioengineering, Rehabilitation. Springer Science & Business Media. p. 398. ISBN 978-1-4419-0754-7. Retrieved 9 November 2014.
- Dohse, K.C. (2007). Effects of Field of View and Stereo Graphics on Memory in Immersive Command and Control. ProQuest. p. 6. ISBN 978-0-549-33503-0. Retrieved 9 November 2014.
- Spring, K. H.; Stiles, W. S. (1948). "APPARENT SHAPE AND SIZE OF THE PUPIL VIEWED OBLIQUELY". British Journal of Ophthalmology 32 (6): 347–354. doi:10.1136/bjo.32.6.347. ISSN 0007-1161. PMC 510837. PMID 18170457.
- Fedtke, Cathleen; Manns, Fabrice; Ho, Arthur (2010). "The entrance pupil of the human eye: a three-dimensional model as a function of viewing angle". Optics Express 18 (21): 22364–76. doi:10.1364/OE.18.022364. ISSN 1094-4087. PMC 3408927. PMID 20941137.
- Mathur, A.; Gehrmann, J.; Atchison, D. A. (2013). "Pupil shape as viewed along the horizontal visual field". Journal of Vision 13 (6): 3–3. doi:10.1167/13.6.3. ISSN 1534-7362.
- MIL-STD-1472F, Military Standard, Human Engineering, Design Criteria For Military Systems, Equipment, And Facilities (23 Aug 1999) PDF
- Ivergard, Toni; Hunt, Brian (1 October 2008). Handbook of Control Room Design and Ergonomics: A Perspective for the Future, Second Edition. CRC Press. p. 90. ISBN 978-1-4200-6434-6. Retrieved 15 October 2014.
- Kaschke, Michael; Donnerhacke, Karl-Heinz; Rill, Michael Stefan (25 November 2013). Optical Devices in Ophthalmology and Optometry: Technology, Design Principles and Clinical Applications. Wiley. p. 26. ISBN 978-3-527-64899-3. Retrieved 15 October 2014.
- Banterle, Francesco; Artusi, Alessandro; Debattista, Kurt; Alan Chalmers (10 February 2011). Advanced High Dynamic Range Imaging: Theory and Practice. CRC Press. p. 7. ISBN 978-1-56881-719-4. Retrieved 15 October 2014.
- Pode, Ramchandra; Diouf, Boucar (15 September 2011). Solar Lighting. Springer Science & Business Media. p. 62. ISBN 978-1-4471-2134-3. Retrieved 16 October 2014.
- Davson, Hugh (2 December 2012). The Physiology of The Eye. Elsevier. p. 213. ISBN 978-0-323-14394-3. Retrieved 15 October 2014.
- Denton, E. J.; Pirenne, Maurice Henri (Mar 29, 1954), "The absolute sensitivity and functional stability of the human eye", The Journal of Physiollogy (The Physiollogical Society) 123 (3): 417–442, doi:10.1113/jphysiol.1954.sp005062, PMC 1366217, PMID 13152690, retrieved Oct 18, 2014
- Narisada, Kohei; Schreuder, Duco (30 November 2004). Light Pollution Handbook. Springer Science & Business Media. p. 8. ISBN 978-1-4020-2665-2. Retrieved 15 October 2014.
- Timiras, Paola S. (16 August 2007). Physiological Basis of Aging and Geriatrics, Fourth Edition. CRC Press. p. 113. ISBN 978-1-4200-0709-1. Retrieved 18 October 2014.
- McGee, Steven R. (2012). Evidence-based Physical Diagnosis. Elsevier Health Sciences. p. 161. ISBN 1-4377-2207-5. Retrieved 18 October 2014.
- Westheimer, Gerald; McKee, Suzanne P (1975). "Visual acuity in the presence of retinal-image motion". Journal of the Optical Society of America 65 (7): 847–50. doi:10.1364/josa.65.000847. PMID 1142031.
- Roger H.S. Carpenter (1988); Movements of the eyes (2nd ed.). Pion Ltd, London. ISBN 0-85086-109-8.
- Saladin, Kenneth S. Anatomy & physiology : the unity of form and function (6th ed.). New York, NY: McGraw-Hill. pp. 620–622. ISBN 978-0-07-337825-1.
- "Human eye". Encyclopædia Britannica. Retrieved 20 November 2012.
- Mendell, Mark J. (22 April 2004). "Non-Specific Symptoms In Office Workers: A Review And Summary Of The Epidemiologic Literature". Indoor Air 3 (4): 227–236. doi:10.1111/j.1600-0668.1993.00003.x. Retrieved 20 November 2012.
- Wolkoff, P; Skov, P; Franck, C; Petersen, LN (December 2003). "Eye irritation and environmental factors in the office environment—hypotheses, causes and a physiological model". Scandinavian journal of work, environment & health 29 (6): 411–30. doi:10.5271/sjweh.748. PMID 14712848. Retrieved 20 November 2012.
- Norn, M (April 1992). "Pollution keratoconjunctivitis. A review". Acta ophthalmologica 70 (2): 269–73. doi:10.1111/j.1755-3768.1992.tb04136.x. PMID 1609579.
- Versura, P; Profazio, V; Cellini, M; Torreggiani, A; Caramazza, R (1999). "Eye discomfort and air pollution". Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 213 (2): 103–109. doi:10.1159/000027401. PMID 9885386.
- Lemp, MA (November 1999). "The 1998 Castroviejo Lecture. New strategies in the treatment of dry-eye states". Cornea 18 (6): 625–32. doi:10.1097/00003226-199911000-00001. PMID 10571289.
- Rolando, M; Zierhut, M (March 2001). "The ocular surface and tear film and their dysfunction in dry eye disease". Survey of ophthalmology. 45 Suppl 2: S203–10. doi:10.1016/S0039-6257(00)00203-4. PMID 11587144.
- Murata, K; Araki, S; Kawakami, N; Saito, Y; Hino, E (1991). "Central nervous system effects and visual fatigue in VDT workers". International archives of occupational and environmental health 63 (2): 109–13. doi:10.1007/BF00379073. PMID 1889879.
- Rossignol, AM; Morse, EP; Summers, VM; Pagnotto, LD (February 1987). "Video display terminal use and reported health symptoms among Massachusetts clerical workers". Journal of occupational medicine: official publication of the Industrial Medical Association 29 (2): 112–8. PMID 3819890.
- Apter, A; Bracker, A; Hodgson, M; Sidman, J; Leung, WY (August 1994). "Epidemiology of the sick building syndrome". The Journal of Allergy and Clinical Immunology 94 (2 Pt 2): 277–88. doi:10.1053/ai.1994.v94.a56006. PMID 8077580.
- Thomson, W. David (March 1998). "Eye problems and visual display terminals—the facts and the fallacies". Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) 18 (2): 111–9. doi:10.1046/j.1475-1313.1998.00323.x. PMID 9692030. Retrieved 20 November 2012.
- Aronsson, G; Strömberg, A (1995). "Work Content and Eye Discomfort in VDT Work". International journal of occupational safety and ergonomics : JOSE 1 (1): 1–13. PMID 10603534.
- Mocci, F; Serra, A; Corrias, GA (April 2001). "Psychological factors and visual fatigue in working with video display terminals". Occupational and Environmental Medicine 58 (4): 267–71. doi:10.1136/oem.58.4.267. PMC 1740121. PMID 11245744. Retrieved 20 November 2012.
- Kjaergaard, SK (2001). Indoor air quality handbook: Chapter 17, the Irritated Eye in the Indoor Environment ([Online-Ausg.]. ed.). New York: McGraw-Hill. ISBN 978-0-07-445549-4.
- Norn, Mogens S. (1974). External eye : methods of examination. Copenhagen: Sciptor. ISBN 978-8787473033.
- Sibony PA, Evinger C. Anatomy and physiology of normal and abnormal eyelid position and movement. In: Miller NR, Newman NJ, editors. Walsh & Hoyt’s clinical neuro-ophthalmology. Baltimore (MD): Williams and Wilkins; 1998. P 1509–92
- Franck, C; Bach, E; Skov, P (1993). "Prevalence of objective eye manifestations in people working in office buildings with different prevalences of the sick building syndrome compared with the general population". International archives of occupational and environmental health 65 (1): 65–9. doi:10.1007/BF00586061. PMID 8354577.
- Franck, C (December 1991). "Fatty layer of the precorneal film in the 'office eye syndrome'". Acta ophthalmologica 69 (6): 737–43. doi:10.1111/j.1755-3768.1991.tb02052.x. PMID 1789088.
- Franck, C; Skov, P (February 1989). "Foam at inner eye canthus in office workers, compared with an average Danish population as control group". Acta ophthalmologica 67 (1): 61–8. doi:10.1111/j.1755-3768.1989.tb00724.x. PMID 2773640.
- Franck, C (June 1986). "Eye symptoms and signs in buildings with indoor climate problems ('office eye syndrome')". Acta ophthalmologica 64 (3): 306–11. doi:10.1111/j.1755-3768.1986.tb06925.x. PMID 3751520.
- Doughty, MJ; Fonn, D; Richter, D; Simpson, T; Caffery, B; Gordon, K (August 1997). "A patient questionnaire approach to estimating the prevalence of dry eye symptoms in patients presenting to optometric practices across Canada". Optometry and vision science : official publication of the American Academy of Optometry 74 (8): 624–31. doi:10.1097/00006324-199708000-00023. PMID 9323733.
- Fonn, D; Situ, P; Simpson, T (October 1999). "Hydrogel lens dehydration and subjective comfort and dryness ratings in symptomatic and asymptomatic contact lens wearers". Optometry and vision science : official publication of the American Academy of Optometry 76 (10): 700–4. doi:10.1097/00006324-199910000-00021. PMID 10524785.
- Vajdic, C; Holden, BA; Sweeney, DF; Cornish, RM (October 1999). "The frequency of ocular symptoms during spectacle and daily soft and rigid contact lens wear". Optometry and vision science: official publication of the American Academy of Optometry 76 (10): 705–11. doi:10.1097/00006324-199910000-00022. PMID 10524786.
- Seal, D. V., and I. A. Mackie. 1986. The questionable dry eye as a clinical and biochemical entity. In F. J. Holly (Ed.), the preocular tear film – In health, disease, and contact lens wear. Dry Eye Institute, Lubbock, Texas, 41- 51
- Hikichi, T; Yoshida, A; Fukui, Y; Hamano, T; Ri, M; Araki, K; Horimoto, K; Takamura, E; Kitagawa, K; Oyama, M (September 1995). "Prevalence of dry eye in Japanese eye centers". Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 233 (9): 555–8. doi:10.1007/BF00404705. PMID 8543205.
- McCarty, C; Bansal, AK; Livingston, PM; Stanislavsky, YL; Taylor, HR (June 1998). "The epidemiology of dry eye in Melbourne, Australia, Historical image". Ophthalmology 105 (6): 1114–1119. doi:10.1016/S0161-6420(98)96016-X. PMID 9627665. Retrieved 20 November 2012.
- Bentivoglio, AR; Bressman, SB; Cassetta, E. Caretta D; Tonali, P; Albanese, A. (1997). "Analysis of blink rate patterns in normal subjects". Mov Disord: 1028–34.
- Mathers, WD; Lane, JA; Zimmerman, MB (May 1996). "Tear film changes associated with normal aging". Cornea 15 (3): 229–34. doi:10.1097/00003226-199605000-00001. PMID 8713923.
- Mathers, WD; Stovall, D; Lane, JA; Zimmerman, MB; Johnson, S (July 1998). "Menopause and tear function: the influence of prolactin and sex hormones on human tear production". Cornea 17 (4): 353–8. doi:10.1097/00003226-199807000-00002. PMID 9676904.
- Heating, American Society of; Refrigerating,; Engineers, Air-Conditioning (1986). Managing indoor air for health and energy conservation : proceedings of the ASHRAE conference IAQ '86, April 20–23, 1986, Atlanta, Georgia, U.S.A. Atlanta, GA: American Society of Heating, Refrigerating and Air-Conditioning Engineers. p. 448. ISBN 978-0-910110-48-8.
- Jaakkola, MS; Jaakkola, JJ (1 December 1999). "Office equipment and supplies: a modern occupational health concern?". American Journal of Epidemiology 150 (11): 1223–8. doi:10.1093/oxfordjournals.aje.a009949. PMID 10588083. Retrieved 20 November 2012.
- Nordström, K; Norbäck, D; Akselsson, R (March 1995). "Influence of indoor air quality and personal factors on the sick building syndrome (SBS) in Swedish geriatric hospitals". Occupational and Environmental Medicine 52 (3): 170–6. doi:10.1136/oem.52.3.170. PMC 1128182. PMID 7735389.
- Anderson, RC; Anderson, JH (1999). "Sensory irritation and multiple chemical sensitivity". Toxicology and industrial health 15 (3–4): 339–45. doi:10.1177/074823379901500308. PMID 10416286.
- Hu, X; Wegman, DH; Eisen, EA; Woskie, SR; Smith, RG (October 1992). "Dose related acute irritant symptom responses to occupational exposure to sodium borate dusts". British journal of industrial medicine 49 (10): 706–13. doi:10.1136/oem.49.10.706. PMC 1012146. PMID 1419859.
- Carney, LG; Hill, RM (June 1982). "The nature of normal blinking patterns". Acta ophthalmologica 60 (3): 427–33. doi:10.1111/j.1755-3768.1982.tb03034.x. PMID 7136554.
- Henning, Robert A.; JACQUES, PIERRE; KISSEL, GEORGE V.; Sullivan, Anne B.; Alteras-Webb, Sabina M. (January 1997). "Frequent short rest breaks from computer work: effects on productivity and well-being at two field sites". Ergonomics 40 (1): 78–91. doi:10.1080/001401397188396. PMID 8995049. Retrieved 20 November 2012.
- Nakamori, K; Odawara, M; Nakajima, T; Mizutani, T; Tsubota, K (July 1997). "Blinking is controlled primarily by ocular surface conditions". American journal of ophthalmology 124 (1): 24–30. doi:10.1016/s0002-9394(14)71639-3. PMID 9222228.
- Barbato, G; Ficca, G; Muscettola, G; Fichele, M; Beatrice, M; Rinaldi, F (Mar 6, 2000). "Diurnal variation in spontaneous eye-blink rate". Psychiatry Research 93 (2): 145–51. doi:10.1016/S0165-1781(00)00108-6. PMID 10725531.
- Sotoyama, M; Villanueva, MB; Jonai, H; Saito, S (1995). "Ocular surface area as an informative index of visual ergonomics". Industrial health 33 (2): 43–55. doi:10.2486/indhealth.33.43. PMID 7493821. Retrieved 20 November 2012.
- Sotoyama, Midori; Jonai, H; Saito, S; Villanueva, MB (June 1996). "Analysis of ocular surface area for comfortable VDT workstation layout". Ergonomics 39 (6): 877–84. doi:10.1080/00140139608964508. PMID 8681929. Retrieved 20 November 2012.
- Collins, M; Heron, H; Larsen, R; Lindner, R (February 1987). "Blinking patterns in soft contact lens wearers can be altered with training". American journal of optometry and physiological optics 64 (2): 100–3. doi:10.1097/00006324-198702000-00004. PMID 3826282.
- Piccoli, B; Assini, R; Gambaro, S; Pastoni, F; D'Orso, M; Franceschin, S; Zampollo, F; De Vito, G (May 15, 2001). "Microbiological pollution and ocular infection in CAD operators: an on-site investigation". Ergonomics 44 (6): 658–67. doi:10.1080/00140130117916. PMID 11373026. Retrieved 20 November 2012.
- Lozato, PA; Pisella, PJ; Baudouin, C (June 2001). "The lipid layer of the lacrimal tear film: physiology and pathology". Journal francais d'ophtalmologie 24 (6): 643–58. PMID 11460063.
- Heritage, Stuart (14 June 2013). "Eyeball-licking: the fetish that is making Japanese teenagers sick". The Guardian. Retrieved 14 June 2013.
- AgingEye Times
- The Eye Diseases Prevalence Research Group*. Prevalence of Age-Related Macular Degeneration in the United States. “Arch Ophthalmol”. 2004;122(4):564–572. doi:10.1001/archopht.122.4.564.
- Bone, R. A., Landrum, J. T., Dixon, Z., Chen, Y., & Llerena, C. M. (2000). Lutein and zeaxanthin in the eyes, serum and diet of human subjects. “Experimental Eye Research”, 71(3), 239–245.
- Semba, R. D., & Dagnelie, G. (2003). Are lutein and zeaxanthin conditionally essential nutrients for eye health?. “Medical Hypotheses”, 61(4), 465–472.
- Johnson, E. J., Hammond, B. R., Yeum, K. J., Qin, J., Wang, X. D., Castaneda, C., Snodderly, D. M., & Russell, R. M. (2000). Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. “American Society for Clinical Nutrition”, 71(6), 1555–1562
- American Optometric Association (2013). “Lutein and zeaxanthin” . Retrieved from http://www.aoa.org/patients-and-public/caring-for-your-vision/diet-and-nutrition/lutein.
- American Optometric Association (2013). “Lutein and zeaxanthin” . Retrieved from http://www.aoa.org/patients-and-public/caring-for-your-vision/diet-and-nutrition/lutein
|Wikimedia Commons has media related to Human eyes.|