Human interactions with fungi
Human interactions with fungi include both beneficial uses, whether practical or symbolic, and harmful interactions such as when fungi damage crops, timber, or food.
Yeasts have been used since ancient times to leaven bread and to ferment beer and wine. More recently, mould fungi have been exploited to create a wide range of industrial products, including enzymes and drugs. Medicines based on fungi include antibiotics, immunosuppressants, statins and many anti-cancer drugs. The yeast species Saccharomyces cerevisiae is an important model organism in cell biology. The fruiting bodies of some larger fungi are collected as edible mushrooms, including delicacies like the chanterelle, cep, and truffle, while a few species are cultivated. Mould fungi provide the meaty (umami) flavour of fermented soybean products such as tempeh, miso and soy sauce, and contribute flavour and colour to blue cheeses including Roquefort and Stilton. Moulds also yield vegetarian meat substitutes like Quorn. Some fungi, especially the fly agaric and psilocybin mushrooms are used for the psychoactive drugs that they contain; these in particular are the focus of academic study in the field of ethnomycology. Fungi have appeared, too, from time to time, in literature and art.
Fungi create harm by spoiling food, destroying timber, and by causing diseases of crops, livestock, and humans. Fungi, mainly moulds like Penicillium and Aspergillus, spoil many stored foods. Fungi cause the majority of plant diseases, which in turn cause serious economic losses. Sometimes, as in the Great Irish Famine of 1845–1849, fungal diseases of plants, in this case potato blight caused by Phytophthora, result in large-scale human suffering. Fungi are similarly the main cause of economic losses of timber in buildings. Finally, fungi cause many diseases of humans and livestock; Aspergillosis kills some 600,000 people a year, mainly however those with already weakened immune systems.
- 1 Context
- 2 Practical uses
- 3 Symbolic uses
- 4 Harmful interactions
- 5 Notes
- 6 References
Culture consists of the social behaviour and norms found in human societies and transmitted through social learning. Cultural universals in all human societies include expressive forms like art, music, dance, ritual, religion, and technologies like tool usage, cooking, shelter, and clothing. The concept of material culture covers physical expressions such as technology, architecture and art, whereas immaterial culture includes principles of social organization, mythology, philosophy, literature, and science. This article describes the roles played by fungi in human culture.
Yeasts have been used since ancient times to leaven bread and to ferment beer and wine. More recently, fungi have been used for a wide variety of industrial fermentations, whether working directly for their effects on materials such as processing paper pulp or bioremediating industrial waste, or serving as the source of enzymes for many purposes, such as fading and softening denim for fashionable blue jeans. Fungi yield a wide variety of industrial enzymes including amylases, invertases, cellulases and hemicellulases, pectinases, proteases, laccases, phytases, alpha-glucuronidases, mannanases, and lipases.
The fruiting bodies of many larger fungi such as the chanterelle and the cep are collected as edible mushrooms. Some, such as truffles, are esteemed as costly delicacies. A few species such as Agaricus bisporus and oyster mushrooms (Pleurotus spp.) are cultivated.
Mould fungi are the source of the meaty (umami) flavour of the soybean products tempeh, miso and soy sauce. Tempeh has been produced in Java since the 13th century. Like tofu, it is made into protein-rich blocks, but these have a firm texture and earthy flavour, since (unlike tofu) the whole beans are retained, providing a higher content of dietary fibre and vitamins. Miso too is rich in protein, vitamins and minerals. It is fermented from a mixture of soybeans and cereals, forming a soft paste used to flavour soups and other Japanese dishes. Soy sauce has been used in China since the 2nd century AD, and is now widespread in Asia. Like miso, it is made by fermenting a mixture of soybeans and cereals with moulds such as Aspergillus oryzae.
The mould Penicillium roqueforti contributes the blue coloration and much of the flavour in blue cheeses such as Roquefort and Stilton. Mould fungi are processed to produce vegetarian meat substitutes such as Quorn.
In modern medicine
Fungi are the sources of many types of medicinal drug including antibiotics, immunosuppressants, and statins. Major classes of antibiotics, the penicillins and the cephalosporins, are derived from substances produced by fungi. So also are the immunosuppressant macrolides, the cyclosporins.
In folk medicine
Many fungi have been used as folk medicines around the world, including in Europe and in India where traditions are well documented. Some have been found to have useful active ingredients, though these do not always correspond with traditional uses of the fungi concerned. Ergot and various cereal smuts, such as Ustilago tritici (wheat grain smut) were used for disorders of pregnancy. Yeasts, made into a boiled paste with wheat flour, were used in India to treat fevers and dysentery. Wounds were treated in Europe with moulds, using for example a slice of mouldy bread or mouldy wheat straw, with active ingredients patulin and other penicillin-like compounds.
The yeast species Saccharomyces cerevisiae has been an important model organism in modern cell biology for much of the twentieth century, and is one of the most thoroughly researched eukaryotic microorganisms. It was the first eukaryote whose genome was sequenced. In the twentyfirst century, the filamentous mould Aspergillus has been adopted for genome studies.
In pest control
Entomopathogenic fungi infect and kill insects, including a variety of pest species, so they have been investigated as possible biological control agents. A variety of Ascomycetes, including Beauveria, Lecanicillium, Metarhizium, and Paecilomyces have promising features for use as biological insecticides. Metarhizium in particular can help to control outbreaks of locusts.
In religion and witchcraft
Some species such as the fly agaric and psilocybin mushrooms are used for the psychoactive drugs that they contain. These are the focus of academic study and intense debate in the field of ethnomycology. In the 1950s, the American banker Robert Gordon Wasson participated in a Mazatec psilocybin mushroom ritual, and wrote an influential but controversial book claiming that the Soma mentioned in the Rigveda was Amanita muscaria, the fly agaric.[a] The mycologist John Ramsbottom however confirmed one element that Allegro later wove into his theory, stating in 1953 that the tree of the knowledge of good and evil fresco[b] in the Plaincourault Chapel depicted Amanita muscaria.[c]
The ergot fungi whose sclerotia appear as "black grain" in rye and other cereals are implicated in the witch trials of 17th century Norway, where the hallucinations caused by ergotism, with visions of Satan as a black dog or cat, caused people to be accused of witchcraft. People in other cultures such as the Aztecs brewed drinks with ergot, which contains alkaloids based on lysergic acid.
In literature and art
Fungi have appeared from time to time in literature, both for children and for adults. In Lewis Carroll's 1865 Alice's Adventures in Wonderland, Alice grows larger if she eats one side of the mushroom, and shrinks if she eats from the other side. Shakespeare has Prospero remark in The Tempest that elves "make midnight mushrooms". Poems and novels about or mentioning fungi have been written by Edmund Spenser, Percy Bysshe Shelley, Keats, Tennyson, Arthur Conan Doyle, D. H. Lawrence, and Emily Dickinson. Tennyson referred to the fairy ring mushroom (Marasmius) with the phrase "the fairy footings on the grass".
Fungi sometimes feature in works of art, such as by Paolo Porpora in the late 17th century. The children's author Beatrix Potter painted hundreds of accurate watercolour illustrations of fungi. More recently, artists such as Martin Belou, Helen Downie (alias "Unskilled Worker"), and Steffen Dam have created installations and paintings of mushrooms.
Fungi, especially moulds but also yeasts, are important agents of food spoilage. Penicillium moulds cause soft rot such as of apples, while Aspergillus moulds create patches on the surface of old bread, yoghurt and many other foods. Yeasts spoil sugary foods such as plums and jams, fermenting the sugars to alcohol. Scientific understanding of spoilage began in the 19th century with works such as Louis Pasteur's 1879 Studies on Fermentation, which investigated the spoilage of beer.
Destruction of timber
Saprotrophic wood-decay fungi are the primary cause of decomposition of wood, causing billions of dollars of economic damage each year. Fungal decay, while useful in composting, is destructive of timber exposed to the weather, and in the case of dry rot caused by Serpula lacrymans, also of timbers in largely dry houses. Some wood-decay fungi such as the honey fungi, species of Armillaria, are parasites of living trees, attacking their roots and eventually killing them, and continuing to decompose the wood when they are dead. Honey fungus is a serious horticultural pest, as it can spread from tree to tree by long strap-shaped rhizomorphs in the soil.
Diseases of crops
Fungi are important crop pathogens, as they reproduce rapidly, affect a wide range of crops around the world, cause some 85% of plant diseases, and can create serious economic losses. The range of types of fungi involved is also wide, including Ascomycetes such as Fusarium causing wilt, Basidiomycetes such as Ustilago causing smuts and Puccinia causing cereal rusts, and Oomycetes such as Phytophthora causing potato late blight and the resulting Great Irish Famine of 1845-1849. Where crop diversity is low, and in particular where single varieties of major crops are nearly universal, fungal diseases can cause the loss of an entire crop, as with the potato in Ireland, and as with the monocultured crop of maize (corn) in the USA in 1970, where over a billion dollars' worth of production was lost. Similarly, the 'Gros Michel' seedless banana crop was essentially completely destroyed worldwide in the 1950s by the wild fungus, Fusarium oxysporum. It was replaced by the Cavendish banana, which in turn was in 2015 facing total destruction by the same disease.
Diseases of humans and livestock
Pathogenic fungi cause a variety of diseases in humans and livestock. Aspergillosis, most commonly caused by Aspergillus fumigatus, kills some 600,000 people per year, mostly those with already weakened immune systems. Pneumocystis causes pneumonia, again mainly in people with weakened immune systems. Candida yeasts are the agents of Candidiasis, causing infections of the mouth, throat, and genital tract, and more seriously of the blood. Ringworm is a skin infection that infects some 20% of the human population; it is caused by some 40 different fungi.
- Michael Hoffman wrote: Wasson neglects to address the relevant question of whether the tree of life at the end of the Bible meant Amanita mushrooms. He asserts that the tree of life in Genesis meant Amanita, while implying that the tree of life in Revelation did not mean Amanita – an unlikely combination of ideas, which he fails to address and justify.
- The Plaincourault Chapel fresco of the tree of the knowledge of good and evil has been photographed in detail on Flickr by Giorgio Samorini.
- Ramsbottom wrote: "The Fly-Agaric is one of the easiest fungi to recognise and to describe. Consequently its poisonous properties were early known ... In a fresco in a ruined chapel at Plaincourault (Indre, France), dating from 1291, a branched specimen is painted to represent the tree of good and evil (Pl. Ib, pg. 34). Presumably it was the artist's conception of the essence of evil made more terrible by enlargement and proliferation. The serpent is shown winding round the stem, offering the traditional apple to Eve, who, apparently having eaten of the 'tree', is shown in an attitude which suggests that she is 'suffering from colic rather than from shame'."
- Macionis, John J.; Gerber, Linda Marie (2011). Sociology. Pearson Prentice Hall. p. 53. ISBN 978-0137001613. Archived from the original on 18 August 2017. Retrieved 29 May 2017.
- Legras JL, Merdinoglu D, Cornuet JM, Karst F. (2007). "Bread, beer and wine: Saccharomyces cerevisiae diversity reflects human history". Molecular Ecology. 16 (10): 2091–2102. doi:10.1111/j.1365-294X.2007.03266.x. PMID 17498234.CS1 maint: Uses authors parameter (link)
- "The importance of fungi". Royal Botanic Gardens Kew. Retrieved 4 November 2016.
- De Lourdes, Maria; Polizeli, T. M.; Rai, Mahendra (2013). Fungal Enzymes. CRC Press. ISBN 978-1-4665-9454-8.
- Hall IR, Lyon AJ, Wang Y, Sinclair L (1998). "Ectomycorrhizal fungi with edible fruiting bodies 2. Boletus edulis". Economic Botany. 52 (1): 44–56. doi:10.1007/BF02861294.
- Persson O. (1997). The Chanterelle Book. Berkeley, California: Ten Speed Press. ISBN 978-0-89815-947-9.
- Brillat-Savarin, Jean Anthelme (1838) . Physiologie du goût. Paris: Charpentier. English translation Archived 2008-07-06 at the Wayback Machine
- "Making Money by growing Mushrooms" (PDF). Food and Agriculture Organization of the United Nations. Retrieved 18 July 2016.
- Hendri F. Isnaeni (9 July 2014). "Sejarah Tempe" (in Indonesian). Historia. Retrieved 16 December 2016.
- Dragonwagon, Crescent; Gourley, Robbin (2002). Passionate Vegetarian. Workman Publishing. p. 639. ISBN 978-1-563-05711-3.
- Steinkraus, Keith H., ed. (1989). Industrialization of indigenous fermented foods. New York: M. Dekker. pp. 99–112. ISBN 978-0824780746.
- Leboffe, Michael; Pierce, Burton. Microbiology Laboratory Theory and Application. Morton. 2nd edition, p.317. ISBN 978-0-895-82947-4
- Kinsella, J.E.; Hwang, D.H. (November 1976). "Enzymes of Penicillium roqueforti involved in the biosynthesis of cheese flavour". Crit Rev Food Sci Nutr. 8 (2): 191–228. doi:10.1080/10408397609527222. PMID 21770.
- Tolbert, Jonathan A. (2003). "Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors". Nature Reviews Drug Discovery. 2 (7): 517–526. doi:10.1038/nrd1112. PMID 12815379.
- Jahromi, M. F; Liang, J. B; Ho, Y. W; Mohamad, R; Goh, Y. M; Shokryazdan, P (2012). "Lovastatin production by Aspergillus terreus using agro-biomass as substrate in solid state fermentation". Journal of Biomedicine & Biotechnology. 2012: 1–11. doi:10.1155/2012/196264. PMC 3478940. PMID 23118499.
- Nicoletti, Rosaria; Ciavatta, Maria Letizia; Buommino, Elisabetta; Tufano, Maria Antonietta (2008). "Antitumor extrolites produced by Penicillium species" (PDF). International Journal of Biomedical and Pharmaceutical Sciences. 2 (1): 1–23. Archived from the original (PDF) on 26 December 2014.
- "Antitumor extrolites produced by Penicillium species" (PDF). Archived from the original (PDF) on 26 December 2014.
- Vaidya, J. G.; Rabba, A. S. (August 1993). "Fungi in Folk Medicine". Mycologist. 7 (3): 131–133. doi:10.1016/S0269-915X(09)80073-6.
- Ostergaard S, Olsson L, Nielsen J. (2000). "Metabolic Engineering of Saccharomyces cerevisiae". Microbiology and Molecular Biology Reviews. 64 (1): 34–50. doi:10.1128/MMBR.64.1.34-50.2000. PMC 98985. PMID 10704473.CS1 maint: Uses authors parameter (link)
- Machida, M.; Gomi, K., eds. (2010). Aspergillus: Molecular Biology and Genomics. Caister Academic Press. ISBN 978-1-904455-53-0.
- "CSIRO ScienceImage 1367 Locusts attacked by the fungus Metarhizium". CSIRO. Retrieved 1 April 2015.
- Strasser H, Vey A, Butt TM (28 June 2010). "Are There any Risks in Using Entomopathogenic Fungi for Pest Control, with Particular Reference to the Bioactive Metabolites of Metarhizium, Tolypocladium and Beauveria species?". Biocontrol Science and Technology. 10 (6): 717–735. doi:10.1080/09583150020011690.
- Lomer, C.J.; Bateman, R.P.; Johnson, D.L.; Langewald, J.; Thomas, M. (2001). "Biological Control of Locusts and Grasshoppers". Annual Review of Entomology. 46: 667–702. doi:10.1146/annurev.ento.46.1.667. PMID 11112183.
- Guzmán G. (2008). "Hallucinogenic mushrooms in Mexico: An overview". Economic Botany. 62 (3): 404–412. doi:10.1007/s12231-008-9033-8.
- Hoffman, Michael (2006). "Wasson and Allegro on the Tree of Knowledge as Amanita". Archived from the original on 14 August 2007. Retrieved 4 November 2016.
- In 1970, the philologist John Allegro destroyed his career by claiming that the fly agaric was the main focus of worship in the more esoteric sects of Sumerian religion, Judaism and early Christianity.Wasson, R. Gordon (1968). Soma: Divine Mushroom of Immortality. ISBN 978-0-15-683800-9.
- Allegro, John (1970). The Sacred Mushroom and the Cross: The Study of the Nature and Origins of Christianity Within Fertility Cults of the Ancient Near East. Hodder & Stoughton. p. 320. ISBN 978-0-340-12875-6.
- Alm, T. (2003). "The Witch Trials of Finmark, Northern Norway, During the 17th Century: Evidence for Ergotism as a Contributing Factor". Economic Botany. 57 (3): 403–416. doi:10.1663/0013-0001(2003)057[0403:twtofn]2.0.co;2.
- "Ethnomycology". University of East Anglia. Retrieved 4 November 2016.
- "Fungal Folklore". Virtual Museum of Canada. 2003. Retrieved 14 September 2018.
- Farell, Aimee (25 May 2018). "Magic mushrooms: fashion's favourite food". Financial Times. Retrieved 14 September 2018.
- "Registry of Mushrooms in Works of Art". North American Mycological Association. Retrieved 14 September 2018.
- "Registry of Mushrooms in Works of Art | Works attributed to Paolo Porpora". North American Mycological Association. Retrieved 14 September 2018.
- Fleming, Nic (15 February 2016). "Beatrix Potter: Pioneering scientist or passionate amateur?". British Broadcasting Corporation. Retrieved 14 September 2018.
- Pitt, John I.; Hocking, Ailsa D. (2009). Fungi and Food Spoilage. Springer. pp. 169–273 (Penicillium), 275–337 (Aspergillus), 357–382 (Yeasts). ISBN 978-0-387-92206-5.
- Pasteur, Louis (1879) Studies on fermentation: The diseases of beer, their causes, and the means of preventing them. Macmillan.
- "Microorganisms causing decay in trees and wood". University of Minnesota. Retrieved 16 December 2016.
- Carey, Janice; Grant, Colin. "The Treatment of Dry Rot in Historic Buildings". Building Conservation. Retrieved 16 December 2016.
- "Honey fungus". Royal Horticultural Society. Retrieved 16 December 2016.
- "Fungal Diseases". AusVeg. Retrieved 16 December 2016.
- Isleib, Jim (19 December 2012). "Signs and symptoms of plant disease: Is it fungal, viral or bacterial?". Michigan State University. Retrieved 16 December 2016.
- Schumann G. L., D'Arcy C. J,. 2006. Essential Plant Pathology. The American Phytopathological Society. St. Paul. pp. 28–29.
- Singh, Ravi P.; Hodson, David; Huerta-Espino, Julio; Jin, Yue; Njau, Peter; Wanyera, Ruth; Herrera-Foessel, Sybil and Ward, Richard W. (2008). Will Stem Rust Destroy The World's Wheat Crop?. Advances in Agronomy. 98. pp. 272–309. doi:10.1016/S0065-2113(08)00205-8. ISBN 9780123743558.CS1 maint: Multiple names: authors list (link)
- Grünwald, N. J.; Goss, E. M.; Press, C. M. (2008). "Phytophthora ramorum: A pathogen with a remarkably wide host range causing sudden oak death on oaks and ramorum blight on woody ornamentals". Molecular Plant Pathology. 9 (6): 729–40. doi:10.1111/J.1364-3703.2008.00500.X. PMID 19019002.
- Muir, Patricia. "Why does genetic diversity within and among crops matter?". Retrieved September 30, 2013.
- "Panama Disease: An Old Nemesis Rears Its Ugly Head Part 1: The Beginnings of the Banana Export Trades". apsnet.org.
- Tola, Elisabetta (21 January 2015). "Banana variety risks wipeout from deadly fungus wilt". The Guardian. Retrieved 14 June 2016.
- Guinea J, Torres-Narbona M, Gijón P, Muñoz P, Pozo F, Peláez T, de Miguel J, Bouza E (June 2010). "Pulmonary aspergillosis in patients with chronic obstructive pulmonary disease: incidence, risk factors, and outcome". Clin Microbiol Infect. 16 (7): 870–7. doi:10.1111/j.1469-0691.2009.03015.x. PMID 19906275.
- Hughes WT (1996). "Pneumocystis Carinii". In Barron S; et al. (eds.). Barron's Medical Microbiology (4th ed.). University of Texas Medical Branch. ISBN 978-0-9631172-1-2.
- "Types of Fungal Diseases". Centres of Disease Control. 2 December 2014. Retrieved 16 December 2016.