Hurler–Scheie syndrome (also known as "mucopolysaccharidosis type I H-S") is a cutaneous condition, also characterized by mild mental retardation and corneal clouding. Respiratory problems, sleep apnea, and heart disease may develop in adolescence.
It is the subtype of mucopolysaccharidosis type I (MPS I) with intermediate severity. Hurler syndrome is the most severe form, while Scheie syndrome is the least severe form. All forms of MPS I are a spectrum of the same disease. Some clinicians consider the differences between Hurler, Hurler-Scheie, and Scheie syndromes to be arbitrary. Instead, they classify these patients as having "severe", "intermediate", or "attenuated" MPS type I.