|Chemical and physical data|
|Molar mass||356.48 g/mol|
|3D model (Jmol)|
|(what is this?)|
Hycanthone is the schistosomicide approved by the FDA in 1975. It is a metabolite of lucanthone. Hycanthone interferes with parasite nerve function, resulting in paralysis and death. This agent also intercalates into DNA and inhibits RNA synthesis in vitro and shows potential antineoplastic activity.
Hycanthone is shown to be an effective inhibitor of acetylcholinesterase (AChE) from Schistosoma mansoni, but is less potential against AChE from mammalian origin. This might come from differences in the configuration of active center between schistosome and mammalian AChE enzymes..
- Phase II Study of Chemotherapy with Hycanthone for Advanced Colorectal Carcinoma (Completed)
- Phase II Chemotherapy with Hycanthone Mesylate and Flagyl for Advanced Malignant Lymphomas (Completed)
|Solubility||Soluble in ethanol, methanol, DMSO, and water|
|Absorption maximum||233, 258, 329, 438 nm|
|Melting point||173-176 °C|
- NCI Cancer Dictionary
- Hillman, GR; Senft, AW (1975). "Anticholinergic properties of the antischistosomal drug hycanthone". The American journal of tropical medicine and hygiene. 24 (5): 827–834. PMID 1190369.