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Combination of
HydrochlorothiazideThiazide diuretic
TriamterenePotassium-sparing diuretic
Clinical data
Trade namesDyazide, Maxzide, others
AHFS/Drugs.comProfessional Drug Facts
License data
  • AU: C
Routes of
By mouth
ATC code
Legal status
Legal status
CAS Number

Hydrochlorothiazide/triamterene, also known as co-triamterzide, is a fixed-dose combination medication of hydrochlorothiazide and triamterene.[1][2][3] It is used to treat high blood pressure and edema (swelling).[1][2][3] Specifically it is used in those who develop low blood potassium (hypokalemia) when on only hydrochlorothiazide.[1][2] It is taken by mouth.[1][2][3]

Side effects may include nausea, trouble sleeping, dizziness, feeling light headed with standing, kidney problems, allergies, and muscle cramps.[1][2] Other serious side effects may include high blood potassium.[1][2] Use in pregnancy and breastfeeding is not generally recommended.[1][2] Use in those with significant kidney problems is not recommended.[1][2] It decreases blood pressure mainly by hydrochlorothiazide while triamterene decreases the amount of potassium lost.[1][2]

The combination was approved for medical use in the United States in 1965.[4] In 2020, it was the 131st most commonly prescribed medication in the United States, with more than 4 million prescriptions.[5][6]


  1. ^ a b c d e f g h i j "Dyazide- hydrochlorothiazide and triamterene capsule". DailyMed. 31 October 2017. Retrieved 20 August 2020.
  2. ^ a b c d e f g h i j "Maxzide-25- maxzide tablet Maxzide tablet". DailyMed. 20 July 2018. Retrieved 20 August 2020.
  3. ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 76. ISBN 9780857113382.
  4. ^ "Dyazide: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 20 August 2020.
  5. ^ "The Top 300 of 2019". ClinCalc. Retrieved 7 October 2022.
  6. ^ "Hydrochlorothiazide; Triamterene - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.

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