alpha-Hydroxyglutaric acid

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α-Hydroxyglutaric acid
Alpha-hydroxyglutaric acid.png
IUPAC name
2-Hydroxypentanedioic acid
Other names
2-Hydroxyglutaric acid
2889-31-8 N
ChEBI CHEBI:17084 YesY
ChemSpider 42 YesY
Jmol interactive 3D Image
KEGG C02630 YesY
MeSH Alpha-hydroxyglutarate
PubChem 43
Molar mass 148.11 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

α-Hydroxyglutaric acid (2-hydroxyglutaric acid) is an alpha hydroxy acid. In humans the compound is formed by a hydroxyacid-oxoacid transhydrogenase whereas in bacteria is formed by a 2-hydroxyglutarate synthase. The compound can be converted to α-ketoglutaric acid through the action of a 2-hydroxyglutarate dehydrogenase which, in humans, are two enzymes called D2HGDH and L2HGDH. Deficiency in either of these two enzymes lead to a disease known as 2-hydroxyglutaric aciduria.