Hydroxylamine reductase

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hydroxylamine reductase
EC number
CAS number 37256-42-1
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a hydroxylamine reductase (EC is an enzyme that catalyzes the chemical reaction

NH3 + H2O + acceptor hydroxylamine + reduced acceptor

The 3 substrates of this enzyme are NH3, H2O, and acceptor, whereas its two products are hydroxylamine and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with other acceptors. The systematic name of this enzyme class is ammonia:acceptor oxidoreductase. Other names in common use include hydroxylamine (acceptor) reductase, and ammonia:(acceptor) oxidoreductase. This enzyme participates in nitrogen metabolism. It has 2 cofactors: FAD, and Flavoprotein.


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  • Walker GC; Nicholas DJD (1961). "Hydroxylamine reductase from Pseudomonas aeruginosa". Biochim. Biophys. Acta. 49 (2): 361–368. doi:10.1016/0006-3002(61)90135-4. PMID 13782715. 
  • NJ, Ferguson SJ; Allen, JW; Higham, CW; Koppenhofer, A; Zajicek, RS; Watmough, NJ; Ferguson, SJ (2002). "Cytochrome cd1, reductive activation and kinetic analysis of a multifunctional respiratory enzyme". J. Biol. Chem. 277 (5): 3093–100. doi:10.1074/jbc.M108944200. PMID 11709555.