Hydroxymethylglutaryl-CoA reductase (NADPH)
|hydroxymethylglutaryl-CoA reductase (NADPH)|
HMG-CoA reductase tetramer, Human
|PDB structures||RCSB PDB PDBe PDBsum|
|Gene Ontology||AmiGO / QuickGO|
- (R)-mevalonate + CoA + 2 NADP+ (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in biosynthesis of steroids including cholesterol. The statin class of anticholesterol drugs act through inhibiting this enzyme.
The systematic name of this enzyme class is (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating). Other names in common use include:
- hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide
- adenine dinucleotide phosphate), 3-hydroxy-3-methylglutaryl-CoA reductase
- β-hydroxy-β-methylglutaryl coenzyme A reductase
- hydroxymethylglutaryl CoA reductase (NADPH)
- S-3-hydroxy-3-methylglutaryl-CoA reductase
- NADPH-hydroxymethylglutaryl-CoA reductase
- HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA)
- 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
- hydroxymethylglutaryl-CoA reductase (NADPH2).
- Bucher NL, Overath P, Lynen F (1960). "β-Hydroxy-β-methylglutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver". Biochim. Biophys. Acta. 40: 491–501. doi:10.1016/0006-3002(60)91390-1. PMID 13805544.
- Durr IF, Rudney H (1960). "The reduction of β-hydroxy-β-methyl-glutaryl coenzyme A to mevalonic acid". J. Biol. Chem. 235: 2572–8. PMID 13818862.
- Kawachi T, Rudney H (1970). "Solubilization and purification of β-hydroxy-β-methylglutaryl coenzyme A reductase from rat liver". Biochemistry. 9 (8): 1700–5. doi:10.1021/bi00810a008. PMID 4985697.
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