Hydroxysteroid dehydrogenase

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Steroid numbering.

Hydroxysteroid dehydrogenases (HSDs) are a group of alcohol oxidoreductases that catalyze the dehydrogenation of hydroxysteroids. These enzymes also catalyze the reverse reaction, acting as ketosteroid reductases (KSRs).

There are four types, classified by the number of the position acted upon:

Carbon Hydroxysteroid Ketosteroid
3α-HSD 3α-Androstanediol Dihydrotestosterone
3α-HSD 3α-Etiocholanediol 5β-Dihydrotestosterone
3β-HSD Pregnenolone Progesterone
3β-HSD 17α-Hydroxypregnenolone 17α-Hydroxyprogesterone
3β-HSD Dehydroepiandrosterone Androstenedione
3β-HSD Androstenediol Testosterone
11β-HSD Cortisol Cortisone
17β-HSD Androstenedione Testosterone
17β-HSD Androstanedione Dihydrotestosterone
17β-HSD Estrone Estradiol
20β-HSD Progesterone 20α-Dihydroprogesterone

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