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Clinical data
Trade namesAtarax, Vistaril,[1] others
Other namesUCB-4492
License data
Very low[2]
Routes of
By mouth, intramuscular injection
Drug classFirst generation antihistamine[3]
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding93%
MetabolitesCetirizine, others
Elimination half-lifeAdults: 20.0 hours[4][5]
Elderly: 29.3 hours[6]
Children: 7.1 hours[4]
ExcretionUrine, feces
  • (±)-2-(2-{4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl}ethoxy)ethanol
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.000.630 Edit this at Wikidata
Chemical and physical data
Molar mass374.91 g·mol−1
3D model (JSmol)
  • Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)CCOCCO
  • InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2 checkY

Hydroxyzine, sold under the brand names Atarax and others, is an antihistamine medication.[8] It is used in the treatment of itchiness, anxiety, and nausea, including that due to motion sickness.[8] It is used either by mouth or injection into a muscle.[8]

Common side effects include sleepiness, headache, and a dry mouth.[8][9] Serious side effects may include QT prolongation.[9] It is unclear if use during pregnancy or breastfeeding is safe.[8] Hydroxyzine works by blocking the effects of histamine.[9] It is a first-generation antihistamine in the piperazine family of chemicals.[8][3]

It was first made by Union Chimique Belge in 1956 and was approved for sale by Pfizer in the United States later that year.[8][10] In 2018, it was the 78th most commonly prescribed medication in the United States, with more than 10 million prescriptions.[11][12]

Medical uses[edit]

Hydroxyzine is used in the treatment of itchiness, anxiety, and nausea due to motion sickness.[8]

A systematic review concluded that compared with other anxiolytic agents (benzodiazepines and buspirone), hydroxyzine was equivalent in efficacy, acceptability, and tolerability.[13]

Hydroxyzine can also be used for the treatment of allergic conditions, such as chronic urticaria, atopic or contact dermatoses, and histamine-mediated pruritus. These have also been confirmed in both recent and past studies to have no adverse effects on the liver, blood, nervous system, or urinary tract.[14]

Use of hydroxyzine for premedication as a sedative has no effects on tropane alkaloids, such as atropine, but may, following general anesthesia, potentiate meperidine and barbiturates, and use in pre-anesthetic adjunctive therapy should be modified depending upon the state of the individual.[14]

In other cases, the usage of hydroxyzine is as a form of non-barbiturate tranquilizer[15] used in the pre-operative sedation and treatment of neurological disorders, such as psychoneurosis and other forms of anxiety or tension states.[15]

Available forms[edit]

The following salts of hydroxyzine are and/or have been available:[16][17][18]

  • Hydroxyzine hydrochloride (Atarax)
    • Oral tablets: 10 mg, 25 mg, 50 mg, 100 mg
    • Oral film-coated tablets: 10 mg, 25 mg, 50 mg
    • Oral syrup: 10 mg/5 mL
    • Intramuscular injection: 25 mg/mL, 50 mg/mL
  • Hydroxyzine pamoate (Vistaril)
    • Oral capsules: 25 mg, 50 mg, 100 mg
    • Oral suspension: 25 mg/5 mL


The administration of hydroxyzine in large amounts by ingestion or intramuscular administration during the onset of pregnancy can cause fetal abnormalities—when administered to pregnant rats, mice and rabbits, hydroxyzine caused abnormalities such as hypogonadism with doses significantly above that of the human therapeutic range.[19] In humans, a significant dose has not yet been established in studies, and by default, the Food and Drug Administration (FDA) has introduced contraindication guidelines in regard to hydroxyzine.[19] Similarly the use in those at risk from or showing previous signs of hypersensitivity is also contraindicated.[19] Hydroxyzine is contraindicated for intravenous (IV) injection, as it has shown to cause hemolysis.

Other contraindications include the administration of hydroxyzine alongside depressants and other compounds which affect the central nervous system;[19] if absolutely necessary, it should only be administered concomitantly in small doses.[19] If administered in small doses with other substances, such as mentioned, then patients should refrain from using dangerous machinery, motor vehicles or any other practice requiring absolute concentration, in accordance with safety law.[19]

Studies have also been conducted which show that long-term prescription of hydroxyzine can lead to tardive dyskinesia after years of use, but effects related to dyskinesia have also anecdotally been reported after periods of 7.5 months,[20] such as continual head rolling, lip licking and other forms of athetoid movement. In certain cases, elderly patients' previous interactions with phenothiazine derivatives or pre-existing neuroleptic treatment may have had some contribution towards dyskinesia at the administration of hydroxyzine due to hypersensitivity caused due to the prolonged treatment,[20] and therefore some contraindication is given to the short-term administration of hydroxyzine to those with previous phenothiazine use.[20]

Side effects[edit]

Several reactions have been noted in manufacturer guidelines—deep sleep, incoordination, sedation, calmness, and dizziness have been reported in children and adults, as well as others such as hypotension, tinnitus, and headaches.[21] Gastrointestinal effects have also been observed, as well as less serious effects such as dryness of the mouth and constipation caused by the mild antimuscarinic properties of hydroxyzine.[21]

Central nervous system problems such as hallucinations or confusion have been observed in rare cases, attributed mostly to overdosage.[22][21] Such properties have been attributed to hydroxyzine in several cases, particularly in patients treated for neuropsychological disorders, as well as in cases where overdoses have been observed. While there are reports of the "hallucinogenic" or "hypnotic" properties of hydroxyzine, several clinical data trials have not reported such side effects from the sole consumption of hydroxyzine, but rather, have described its overall calming effect described through the stimulation of areas within the formatio reticularis. The hallucinogenic or hypnotic properties have been described as being an additional effect from overall central nervous system suppression by other CNS agents, such as lithium or ethanol.[23]

The effect of hydroxyzine has also been tested on the ability of humans in the registration and storage of memory, and was used in comparison with relatively safe drugs, such as lorazepam, to illustrate the effects of benzodiazepines, which are thought to have adverse effects on the capacity of memory storage. Hydroxyzine was found to have no adverse effects on memory in relation to lorazepam, which caused several deficiencies in the capacity of memory storage.[24]

In a comparative study with lorazepam on memory effects, patients who had taken hydroxyzine experienced sedative effects like drowsiness, but recalled that they felt capable, attentive and able to continue with a memory test under these conditions.[24] Conversely, those under the effects of lorazepam felt unable to continue due to the fact they felt out of control with its effects; 8 out of 10 patients describing tendencies of problems with balance and control of simple motor functions.[24]

Somnolence with or without vivid dreams or nightmares may occur in users with antihistamine sensitivities in combination with other CNS depressants. Hydroxyzine exhibits anxiolytic and sedative properties in many psychiatric patients. Other studies have suggested that hydroxyzine acts as an acute hypnotic, reducing sleep onset latency and increasing sleep duration — also showing that some drowsiness did occur. This was observed more in female patients, who also had greater hypnotic response.[25] The use of sedating drugs alongside hydroxyzine can cause oversedation and confusion if administered in large amounts—any form of treatment alongside sedatives should be done under supervision of a doctor.[15][22]

Because of potential for more severe side effects, this drug is on the list to avoid in the elderly.[26]

In 2015, the European Medicines Agency (EMA) announced a small but definite risk of QT prolongation associated with the use of hydroxyzine. This side effect is more likely to occur in people with pre-existing cardiac disease, or with the use of other medicines known to prolong the QT interval.



Site Ki (nM) Species Ref
5-HT2A 170 (IC50) Rat [28]
α1 460 (IC50) Rat [28]
D1 >10,000 Mouse [29]
D2 378
560 (IC50)
H1 2.0–19
100 (IC50)
H4 >10,000 Human [31]
mACh 4,600
10,000 (IC50)
6,310 (pA2)
Guinea pig
VDCC ≥3,400 (IC50) Rat [28]
Values are Ki (nM), unless otherwise noted. The smaller the value, the more strongly the drug binds to the site.

Hydroxyzine's predominant mechanism of action is as a potent and selective histamine H1 receptor inverse agonist.[36][37] This action is responsible for its antihistamine and sedative effects.[36][37] Unlike many other first-generation antihistamines, hydroxyzine has a lower affinity for the muscarinic acetylcholine receptors, and in accordance, has a lower risk of anticholinergic side effects.[33][37][38][39] In addition to its antihistamine activity, hydroxyzine has also been shown to act more weakly as an antagonist of the serotonin 5-HT2A receptor, the dopamine D2 receptor, and the α1-adrenergic receptor.[28][36] The weak antiserotonergic effects of hydroxyzine likely underlie its usefulness as an anxiolytic,[40] as other antihistamines without such properties have not been found to be effective in the treatment of anxiety.[41]

Hydroxyzine crosses the blood–brain barrier easily and exerts effects in the central nervous system.[36] A positron emission tomography (PET) study found that brain occupancy of the H1 receptor was 67.6% for a single 30 mg dose of hydroxyzine.[42] In addition, subjective sleepiness correlated well with the brain H1 receptor occupancy.[42] PET studies with antihistamines have found that brain H1 receptor occupancy of more than 50% is associated with a high prevalence of somnolence and cognitive decline, whereas brain H1 receptor occupancy of less than 20% is considered to be non-sedative.[43]


Hydroxyzine can be administered orally or via intramuscular injection. When given orally, hydroxyzine is rapidly absorbed from the gastrointestinal tract. The effect of hydroxyzine is notable in 30 minutes.[citation needed]

Hydroxyzine is rapidly absorbed and distributed with oral and intramuscular administration, and is metabolized in the liver; the main metabolite (45%), cetirizine, is formed through oxidation of the alcohol moiety to a carboxylic acid by alcohol dehydrogenase, and overall effects are observed within one hour of administration. Higher concentrations are found in the skin than in the plasma. Cetirizine, although less sedating, is non-dialyzable and possesses similar antihistamine properties. The other metabolites identified include a N-dealkylated metabolite, and an O-dealkylated 1/16 metabolite with a plasma half-life of 59 hours. These pathways are mediated principally by CYP3A4 and CYP3A5.[44] [45] "In animals, hydroxyzine and its metabolites are excreted in feces via biliary elimination."[46]

The Tmax of hydroxyzine is about 2.0 hours in both adults and children and its elimination half-life is around 20.0 hours in adults (mean age 29.3 years) and 7.1 hours in children.[4][5] Its elimination half-life is shorter in children compared to adults.[4] In another study, the elimination half-life of hydroxyzine in elderly adults was 29.3 hours.[6] One study found that the elimination half-life of hydroxyzine in adults was as short as 3 hours, but this may have just been due to methodological limitations.[47] Although hydroxyzine has a long elimination half-life and produces antihistamine for as long as 24 hours, the CNS effects of hydroxyzine and other antihistamines with long half-lives seem to diminish after 8 hours.[48]

Administration in geriatrics differs from the administration of hydroxyzine in younger patients; according to the FDA, there have not been significant studies made (2004), which include population groups over 65, which provide a distinction between elderly aged patients and other younger groups. Hydroxyzine should be administered carefully in the elderly with consideration given to possible reduced elimination.[22]


Hydroxyzine is a member of the diphenylmethylpiperazine class of antihistamines.

Hydroxyzine is supplied mainly as a dihydrochloride salt (hydroxyzine hydrochloride) but also to a lesser extent as an embonate salt (hydroxyzine pamoate).[49][50][51] The molecular weights of hydroxyzine, hydroxyzine dihydrochloride, and hydroxyzine pamoate are 374.9 g/mol, 447.8 g/mol, and 763.3 g/mol, respectively.[52] Due to their differences in molecular weight, 1 mg hydroxyzine dihydrochloride is equivalent to about 1.7 mg hydroxyzine pamoate.[53]


Analogues of hydroxyzine include buclizine, cetirizine, cinnarizine, cyclizine, etodroxizine, meclizine, and pipoxizine among others.


Hydroxyzine is synthesized by the alkylation of 1-(4-chlorobenzhydryl)piperazine with 2-(2-chloroethoxy)ethanol:[54]

Hydroxyzine synthesis.png

Society and culture[edit]

Brand names[edit]

Hydroxyzine preparations require a doctor's prescription. The drug is available in two formulations, the pamoate and the dihydrochloride or hydrochloride salts. Vistaril, Equipose, Masmoran, and Paxistil are preparations of the pamoate salt, while Atarax, Alamon, Aterax, Durrax, Tran-Q, Orgatrax, Quiess, and Tranquizine are of the hydrochloride salt.

Hydroxyzine is also known as Evazine and is referenced in the Russian TV show, To the Lake, season 1 episode 4.


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External links[edit]

  • "Hydroxyzine". Drug Information Portal. U.S. National Library of Medicine.