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Hyperkatifeia is defined as hypersensitivity to emotional distress in the context of opioid abuse.[1]

Hyperkatifeia and Opioid-induced hyperalgesia can be seen with long-term use of elicit street opioids e.g. heroin and prescription opioids e.g. hydrocodone and oxycodone during withdrawal. These two clinical syndromes have been correlated with gross loss of regions of the amygdala and decreases in functional connectivity of corresponding white matter tracts.[2]


  1. ^ Pain Med. 2010 July; 11(7): 1092–1098
  2. ^ [Grandy, John. A Clinical Correlation Made Between Opioid-induced Hyperalgesia and Hyperkatifeia with Brain Alterations Induced by Long-term Prescription Opioid Use. Research & Reviews: A Journal of Neuroscience. 2012 August; 2(2): 1-11]