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Hyperplasia vs Hypertrophy.svg
Hypertrophy results from an increase in cell size, whereas hyperplasia stems from an increase in cell number
Classification and external resources
MeSH D006984
Forensic post-mortem examination of a case of hypertrophic cardiomyopathy, showing thickening of the cardiac muscle.

Hypertrophy (/hˈpɜːrtrəfi/, from Greek ὑπέρ "excess" + τροφή "nourishment") is the increase in the volume of an organ or tissue due to the enlargement of its component cells.[1] It is distinguished from hyperplasia, in which the cells remain approximately the same size but increase in number.[2] Although hypertrophy and hyperplasia are two distinct processes, they frequently occur together, such as in the case of the hormonally-induced proliferation and enlargement of the cells of the uterus during pregnancy.

Eccentric hypertrophy is a type of hypertrophy where the walls and chamber of a hollow organ undergo growth in which the overall size and volume are enlarged. It is applied especially to the left ventricle of heart.[3] Sarcomeres are added in series, as for example in dilated cardiomyopathy (in contrast to hypertrophic cardiomyopathy, a type of concentric hypertrophy, where sarcomeres are added in parallel).

See also[edit]


  1. ^ Hernandez, Richard; Kravitz, Len. "Skeletal muscle hypertrophy". www.unm.edu. 
  2. ^ Updated by Linda J. Vorvick. 8/14/15.Hyperplasia
  3. ^ Kusumoto, F. M. (2004), Cardiovascular Pathophysiology, Hayes Barton Press, pp. 20–22, ISBN 978-1-59377-189-8 

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