|Systematic IUPAC name
3D model (JSmol)
CompTox Dashboard (EPA)
|Conjugate acid||Hypochlorous acid|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
In chemistry, hypochlorite is an anion with the chemical formula ClO−. It combines with a number of cations to form hypochlorites, which may also be regarded as the salts of hypochlorous acid. Common examples include sodium hypochlorite (household bleach) and calcium hypochlorite (a component of bleaching powder, swimming pool "chlorine").
The name can also refer to esters of the hypothetical hypochlorous acid, namely organic compounds with a ClO– group covalently bound to the rest of the molecule. The principal example is tert-butyl hypochlorite, which is a useful chlorinating agent.
Most hypochlorite salts are unstable in their pure forms, and are normally handled as aqueous solutions. Their primary applications are as bleaching, disinfection, and water treatment agents, but they are also used in chemistry for chlorination and oxidation reactions.
Acidification of hypochlorites generates hypochlorous acid. This exists in an equilibrium with chlorine gas, which can bubble out of solution. The equilibrium is subject to Le Chatelier's principle; thus a high pH drives the reaction to the left by consuming H+
ions, promoting the disproportionation of chlorine into chloride and hypochlorite, whereas a low pH drives the reaction to the right, promoting the release of chlorine gas.
- 2 H+
2 + H
- 2 HOCl ⇌ Cl2O + H2O K (at 0 °C) = 3.55×10−3 dm3 mol−1
Hypochlorites are generally unstable and many compounds exist only in solution. Lithium hypochlorite LiOCl, calcium hypochlorite Ca(OCl)2 and barium hypochlorite Ba(ClO)2 have been isolated as pure anhydrous compounds. All are solids. A few more can be produced as aqueous solutions. In general the greater the dilution the greater their stability. It is not possible to determine trends for the alkaline earth metal salts, as many of them cannot be formed. Beryllium hypochlorite is unheard of. Pure magnesium hypochlorite cannot be prepared; however, solid Mg(OH)OCl is known. Calcium hypochlorite is produced on an industrial scale and has good stability. Strontium hypochlorite, Sr(OCl)2, is not well characterised and its stability has not yet been determined.
- 2 ClO−
→ 2 Cl−
- 3 ClO−
→ 2 Cl−
The alkali metal hypochlorites decrease in stability down the group. Anhydrous lithium hypochlorite is stable at room temperature; however, sodium hypochlorite has not be prepared drier than the pentahydrate (NaOCl·(H2O)5). This is unstable above 0 °C; although the more dilute solutions encountered as household bleach possesses better stability. Potassium hypochlorite (KOCl) is known only in solution.
Lanthanide hypochlorites are also unstable; however, they have been reported as being more stable in their anhydrous forms than in the presence of water. Hypochlorite has been used to oxidise cerium from its +3 to +4 oxidation state.
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Reactions with ammonia
3 + ClO−
2Cl + ClO−
2 + ClO−
Several hypochlorites can be formed by a disproportionation reaction between chlorine and metal hydroxides. The reaction is performed at close to room temperature, as further oxidation will occur at higher temperatures leading to the formation of chlorates. This process is widely used for the industrial production of sodium hypochlorite (NaClO) and calcium hypochlorite (Ca(ClO)2).
Large amounts of sodium hypochlorite are also produced electrochemically via an un-separated chloralkali process. In this process brine is electrolyzed to form Cl
2 which dissociates in water to form hypochlorite. This reaction must be run in non-acidic conditions to prevent chlorine gas from bubbling out of solution:
- 2 Cl−
2 + 2 e−
2 + H
2O ⇌ HClO + Cl−
Small amounts of more unusual hypochlorites may also be formed by a salt metathesis reaction between calcium hypochlorite and various metal sulfates. This reaction is performed in water and relies on the formation of insoluble calcium sulfate, which will precipitate out of solution, driving the reaction to completion.
- Ca(ClO)2 + MSO4 → M(ClO)2 + CaSO4
Hypochlorite esters are in general formed from the corresponding alcohols, by treatment with any of a number of reagents (e.g. chlorine, hypochlorous acid, dichlorine monoxide and various acidified hypochlorite salts).
Biosynthesis of organochlorine compounds
Chloroperoxidases are enzymes that catalyzes the chlorination of organic compounds. This enzyme combines the inorganic substrates chloride and hydrogen peroxide to produce the equivalent of Cl+, which replaces a proton in hydrocarbon substrate:
- R-H + Cl− + H2O2 + H+ → R-Cl + 2 H2O
In response to infection, the human immune system generates minute quantities of hypochlorite within special white blood cells, called neutrophil granulocytes. These granulocytes engulf viruses and bacteria in an intracellular vacuole called the phagosome, where they are digested.
Part of the digestion mechanism involves an enzyme-mediated respiratory burst, which produces reactive oxygen-derived compounds, including superoxide (which is produced by NADPH oxidase). Superoxide decays to oxygen and hydrogen peroxide, which is used in a myeloperoxidase-catalysed reaction to convert chloride to hypochlorite.
Low concentrations of hypochlorite were also found to interact with a microbe's heat shock proteins, stimulating their role as intra-cellular chaperone and causing the bacteria to form into clumps (much like an egg that has been boiled) that will eventually die off. The same study found that low (micromolar) hypochlorite levels induce E. coli and Vibrio cholerae to activate a protective mechanism, although its implications were not clear.
Industrial and domestic uses
Hypochlorites, especially of sodium ("liquid bleach", "Javel water") and calcium ("bleaching powder") are widely used, industrially and domestically, to whiten clothes, lighten hair color and remove stains. They were the first commercial bleaching products, developed soon after that property was discovered in 1785 by French chemist Claude Berthollet.
Hypochlorites are also widely used as broad spectrum disinfectants and deodorizers. That application started soon after French chemist Labarraque discovered those properties, around 1820 (still before Pasteur formulated his germ theory of disease).
As oxidizing agents
Hypochlorite is the strongest oxidizing agent of the chlorine oxyanions. This can be seen by comparing the standard half cell potentials across the series; the data also shows that the chlorine oxyanions are stronger oxidizers in acidic conditions.
|Ion||Acidic reaction||E° (V)||Neutral/basic reaction||E° (V)|
|Hypochlorite||H+ + HOCl + e− → 1⁄2 Cl2(g) + H2O||1.63||ClO− + H2O + 2 e− → Cl− + 2OH−||0.89|
|Chlorite||3 H+ + HOClO + 3 e− → 1⁄2 Cl2(g) + 2 H2O||1.64||ClO−
2 + 2 H2O + 4 e− → Cl− + 4 OH−
|Chlorate||6 H+ + ClO−
3 + 5 e− → 1⁄2 Cl2(g) + 3 H2O
3 + 3 H2O + 6 e− → Cl− + 6 OH−
|Perchlorate||8 H+ + ClO−
4 + 7 e− → 1⁄2 Cl2(g) + 4 H2O
4 + 4 H2O + 8 e− → Cl− + 8 OH−
Hypochlorite is a sufficiently strong oxidiser to convert Mn(III) to Mn(V) during the Jacobsen epoxidation reaction and to convert Ce3+
. This oxidising power is what makes them effective bleaching agents and disinfectants.
As chlorinating agents
|Chlorine oxidation state||−1||+1||+3||+5||+7|
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