Hypocretin (orexin) receptor 1

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Hypocretin (orexin) receptor 1
Symbols HCRTR1 ; OX1R
External IDs OMIM602392 MGI2385650 HomoloGene37492 IUPHAR: 321 ChEMBL: 5113 GeneCards: HCRTR1 Gene
RNA expression pattern
PBB GE HCRTR1 207619 at tn.png
More reference expression data
Species Human Mouse
Entrez 3061 230777
Ensembl ENSG00000121764 ENSMUSG00000028778
UniProt O43613 P58307
RefSeq (mRNA) NM_001525 NM_001163027
RefSeq (protein) NP_001516 NP_001156499
Location (UCSC) Chr 1:
31.62 – 31.63 Mb
Chr 4:
130.13 – 130.14 Mb
PubMed search [1] [2]

Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1, is a protein that in humans is encoded by the HCRTR1 gene.[1]


The orexin 1 receptor (OX1), is a G-protein coupled receptor expressed in the hypothalamus and involved in the regulation of feeding behaviour. OX1 selectively binds the orexin-A neuropeptide. It shares 64% identity with OX2.[1]




Further information: Orexin antagonist

See also[edit]


External links[edit]

  • "Orexin Receptors: OX1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.