Hypoprothrombinemia

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Hypoprothrombinemia
Classification and external resources
Specialty hematology
ICD-10 D68.2
ICD-9-CM 286.3, 776.3
eMedicine ped/1133
MeSH D007020

Hypoprothrombinemia is a blood disorder in which a deficiency of prothrombin (Factor II) results in impaired blood clotting, leading to an increased physiological risk for bleeding, especially in the gastrointestinal system, cranial vault, and superficial integumentary system.

Causes[edit]

Hypoprothrombinemia can be the result of a genetic defect, may be acquired as the result of another disease process, or may be an adverse effect of medication. For example, 5-10% of patients with systemic lupus erythematosus exhibit acquired hypoprothrombinemia due to the presence of autoantibodies which bind to prothrombin and remove it from the bloodstream (lupus anticoagulant-hypoprothrombinaemia syndrome).[1]

It may also be a rare adverse effect to Rocephin.[2]

Treatment[edit]

Hypoprothrombinemia can be treated with periodic infusions of purified prothrombin complexes.[3]

  1. A known treatment for hypoprothrombinemia is menadoxime.[4]
  2. Menatetrenone was also listed as a Antihaemorrhagic vitamin.
  3. 4-Amino-2-methyl-1-naphthol (Vitamin K5) is another treatment for hypoprothrombinemia.

References[edit]

  1. ^ Bajaj S, Rapaport S, Fierer D, Herbst K, Schwartz D (1983). "A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome.". Blood. 61 (4): 684–92. PMID 6403077. 
  2. ^ [ http://www.gene.com/download/pdf/rocephin_prescribing.pdf Rocephin proscribing information]. Accessed October 24, 2013.
  3. ^ Lechler E (1999). "Use of prothrombin complex concentrates for prophylaxis and treatment of bleeding episodes in patients with hereditary deficiency of prothrombin, factor VII, factor X, protein C protein S, or protein Z.". Thromb Res. 95 (4 Suppl 1): S39–50. PMID 10499908. doi:10.1016/S0049-3848(99)00083-3. 
  4. ^ J. Elks, C. R. Ganellin · DoDs page 765.