ICAM2

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ICAM2
Protein ICAM2 PDB 1zxq.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesICAM2, CD102, intercellular adhesion molecule 2
External IDsMGI: 96394 HomoloGene: 675 GeneCards: ICAM2
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for ICAM2
Genomic location for ICAM2
Band17q23.3Start64,002,594 bp[1]
End64,020,634 bp[1]
RNA expression pattern
PBB GE ICAM2 204683 at fs.png

PBB GE ICAM2 213620 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001099789
NM_000873
NM_001099786
NM_001099787
NM_001099788

NM_010494

RefSeq (protein)

NP_000864
NP_001093256
NP_001093257
NP_001093258
NP_001093259

NP_034624

Location (UCSC)Chr 17: 64 – 64.02 MbChr 11: 106.38 – 106.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene, and the protein resulting from it.

Protein structure[edit]

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.

Protein functions[edit]

ICAM-2 molecules regulate spermatid adhesion on Sertoli cell on the apical side of the blood-testis barrier (towards the lumen), thus playing a major role in spermatogenesis.[5]

This protein may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.[6]

Interactions[edit]

ICAM2 has been shown to interact with EZR.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108622 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001029 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Xiao X, Mruk DD, Cheng CY (2013). "Intercellular adhesion molecules (ICAMs) and spermatogenesis". Human Reproduction Update. 19 (2): 167–86. doi:10.1093/humupd/dms049. PMC 3576004Freely accessible. PMID 23287428. 
  6. ^ "Entrez Gene: ICAM2 intercellular adhesion molecule 2". 
  7. ^ Heiska L, Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpén O (August 1998). "Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate". The Journal of Biological Chemistry. 273 (34): 21893–900. doi:10.1074/jbc.273.34.21893. PMID 9705328. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.