ICAM2

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ICAM2
Protein ICAM2 PDB 1zxq.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ICAM2, CD102, intercellular adhesion molecule 2
External IDs MGI: 96394 HomoloGene: 675 GeneCards: 3384
RNA expression pattern
PBB GE ICAM2 204683 at tn.png

PBB GE ICAM2 213620 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001099789
NM_000873
NM_001099786
NM_001099787
NM_001099788

NM_010494

RefSeq (protein)

NP_000864.2
NP_001093256.1
NP_001093257.1
NP_001093258.1
NP_001093259.1

NP_034624.1

Location (UCSC) Chr 17: 64 – 64.02 Mb Chr 11: 106.38 – 106.39 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene, and the protein resulting from it.

Protein structure[edit]

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.

Protein functions[edit]

ICAM-2 molecules regulate spermatid adhesion on Sertori cell on the apical side of the blood-testis barrier (towards the lumen), thus playing a major role in spermatogenesis.[1]

This protein may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.[2]

Interactions[edit]

ICAM2 has been shown to interact with EZR.[3]

See also[edit]

References[edit]

  1. ^ Xiao X, Mruk DD, Cheng CY (2013). "Intercellular adhesion molecules (ICAMs) and spermatogenesis". Human Reproduction Update 19 (2): 167–86. doi:10.1093/humupd/dms049. PMC 3576004. PMID 23287428. 
  2. ^ "Entrez Gene: ICAM2 intercellular adhesion molecule 2". 
  3. ^ Heiska L, Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpén O (August 1998). "Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate". The Journal of Biological Chemistry 273 (34): 21893–900. doi:10.1074/jbc.273.34.21893. PMID 9705328. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.