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Available structures
PDB Ortholog search: PDBe RCSB
Aliases ICAM5, TLCN, TLN, intercellular adhesion molecule 5
External IDs MGI: 109430 HomoloGene: 2447 GeneCards: ICAM5
RNA expression pattern
PBB GE ICAM5 206906 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 10.29 – 10.3 Mb Chr 9: 21.03 – 21.04 Mb
PubMed search [1] [2]
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Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene.[3][4][5]

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.[5]


ICAM5 has been shown to interact with PSEN1.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mizuno T, Yoshihara Y, Inazawa J, Kagamiyama H, Mori K (Feb 1997). "cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1". J Biol Chem. 272 (2): 1156–63. doi:10.1074/jbc.272.2.1156. PMID 8995416. 
  4. ^ Kilgannon P, Turner T, Meyer J, Wisdom W, Gallatin WM (Jan 1999). "Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2". Genomics. 54 (2): 328–30. doi:10.1006/geno.1998.5565. PMID 9828136. 
  5. ^ a b "Entrez Gene: ICAM5 intercellular adhesion molecule 5, telencephalin". 
  6. ^ Annaert, W G; Esselens C; Baert V; Boeve C; Snellings G; Cupers P; Craessaerts K; De Strooper B (Nov 2001). "Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins". Neuron. United States. 32 (4): 579–89. doi:10.1016/S0896-6273(01)00512-8. ISSN 0896-6273. PMID 11719200. 

Further reading[edit]