ICI-204,448 is a drug which acts as a potent and peripherally selective κ-opioidagonist, with possible uses in the treatment of heart attack as well as anti-itching effects. It is used in research to distinguish centrally from peripherally mediated kappa opioid receptor effects.
^Peart JN, Gross ER, Gross GJ (March 2004). "Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction". Journal of Cardiovascular Pharmacology. 43 (3): 410–5. doi:10.1097/00005344-200403000-00012. PMID15076225.
^Shannon HE, Eberle EL, Mitch CH, McKinzie DL, Statnick MA (December 2007). "Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats". Neuropharmacology. 53 (8): 930–41. doi:10.1016/j.neuropharm.2007.09.002. PMID17959202.