ICMT

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ICMT
Identifiers
Aliases ICMT, HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT, isoprenylcysteine carboxyl methyltransferase
External IDs MGI: 1888594 HomoloGene: 5735 GeneCards: ICMT
RNA expression pattern
PBB GE ICMT 201609 x at fs.png

PBB GE ICMT 201611 s at fs.png

PBB GE ICMT 201610 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012405
NM_170705

NM_133788

RefSeq (protein)

NP_036537

NP_598549

Location (UCSC) Chr 1: 6.22 – 6.24 Mb Chr 4: 152.3 – 152.31 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein-S-isoprenylcysteine O-methyltransferase is an enzyme that in humans is encoded by the ICMT gene.[3][4][5]

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Dai Q, Choy E, Chiu V, Romano J, Slivka SR, Steitz SA, Michaelis S, Philips MR (Jul 1998). "Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum". J Biol Chem. 273 (24): 15030–4. PMID 9614111. doi:10.1074/jbc.273.24.15030. 
  4. ^ Desrosiers RR, Nguyen QT, Beliveau R (Sep 1999). "The carboxyl methyltransferase modifying G proteins is a metalloenzyme". Biochem Biophys Res Commun. 261 (3): 790–7. PMID 10441503. doi:10.1006/bbrc.1999.0936. 
  5. ^ a b "Entrez Gene: ICMT isoprenylcysteine carboxyl methyltransferase". 

Further reading[edit]