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AliasesICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, inducible T-cell co-stimulator ligand, inducible T-cell costimulator ligand, inducible T cell costimulator ligand
External IDsMGI: 1354701 HomoloGene: 49412 GeneCards: ICOSLG
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for ICOSLG
Genomic location for ICOSLG
Band21q22.3Start44,217,014 bp[1]
End44,240,966 bp[1]
RNA expression pattern
PBB GE ICOSLG 211199 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 21: 44.22 – 44.24 MbChr 10: 78.07 – 78.08 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

ICOS ligand is a protein that in humans is encoded by the ICOSLG gene.[5][6][7] ICOSLG has also been designated as CD275 (cluster of differentiation 275).


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160223 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000732 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  6. ^ Yoshinaga SK, Zhang M, Pistillo J, Horan T, Khare SD, Miner K, Sonnenberg M, Boone T, Brankow D, Dai T, Delaney J, Han H, Hui A, Kohno T, Manoukian R, Whoriskey JS, Coccia MA (October 2000). "Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS". International Immunology. 12 (10): 1439–47. doi:10.1093/intimm/12.10.1439. PMID 11007762. 
  7. ^ "Entrez Gene: ICOSLG inducible T-cell co-stimulator ligand". 

Further reading[edit]

  • Flesch IE (2003). "Inducible costimulator-ligand (ICOS-L)". Journal of Biological Regulators and Homeostatic Agents. 16 (3): 217–9. PMID 12456022. 
  • Ling V, Wu PW, Finnerty HF, Bean KM, Spaulding V, Fouser LA, Leonard JP, Hunter SE, Zollner R, Thomas JL, Miyashiro JS, Jacobs KA, Collins M (February 2000). "Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor". Journal of Immunology. 164 (4): 1653–7. doi:10.4049/jimmunol.164.4.1653. PMID 10657606. 
  • Aicher A, Hayden-Ledbetter M, Brady WA, Pezzutto A, Richter G, Magaletti D, Buckwalter S, Ledbetter JA, Clark EA (May 2000). "Characterization of human inducible costimulator ligand expression and function". Journal of Immunology. 164 (9): 4689–96. doi:10.4049/jimmunol.164.9.4689. PMID 10779774. 
  • Wang S, Zhu G, Chapoval AI, Dong H, Tamada K, Ni J, Chen L (October 2000). "Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS". Blood. 96 (8): 2808–13. PMID 11023515. 
  • Ling V, Wu PW, Miyashiro JS, Marusic S, Finnerty HF, Collins M (June 2001). "Differential expression of inducible costimulator-ligand splice variants: lymphoid regulation of mouse GL50-B and human GL50 molecules". Journal of Immunology. 166 (12): 7300–8. doi:10.4049/jimmunol.166.12.7300. PMID 11390480. 
  • Sperling AI, Bluestone JA (July 2001). "ICOS costimulation: It's not just for TH2 cells anymore". Nature Immunology. 2 (7): 573–4. doi:10.1038/89709. PMID 11429535. 
  • Wang S, Zhu G, Tamada K, Chen L, Bajorath J (April 2002). "Ligand binding sites of inducible costimulator and high avidity mutants with improved function". The Journal of Experimental Medicine. 195 (8): 1033–41. doi:10.1084/jem.20011607. PMC 2193694Freely accessible. PMID 11956294. 
  • Khayyamian S, Hutloff A, Büchner K, Gräfe M, Henn V, Kroczek RA, Mages HW (April 2002). "ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells". Proceedings of the National Academy of Sciences of the United States of America. 99 (9): 6198–203. doi:10.1073/pnas.092576699. PMC 122926Freely accessible. PMID 11983910. 
  • Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT (September 2002). "Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity". Nature Medicine. 8 (9): 1024–32. doi:10.1038/nm745. PMID 12145647. 
  • Kurosawa S, Myers AC, Chen L, Wang S, Ni J, Plitt JR, Heller NM, Bochner BS, Schleimer RP (May 2003). "Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells". American Journal of Respiratory Cell and Molecular Biology. 28 (5): 563–73. doi:10.1165/rcmb.2002-0199OC. PMID 12707012. 
  • Chen XL, Cao XD, Kang AJ, Wang KM, Su BS, Wang YL (June 2003). "In situ expression and significance of B7 costimulatory molecules within tissues of human gastric carcinoma". World Journal of Gastroenterology. 9 (6): 1370–3. doi:10.3748/wjg.v9.i6.1370. PMID 12800259. 
  • Iwai H, Abe M, Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M (September 2003). "Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis". Journal of Immunology. 171 (6): 2848–54. doi:10.4049/jimmunol.171.6.2848. PMID 12960306. 
  • Schreiner B, Wischhusen J, Mitsdoerffer M, Schneider D, Bornemann A, Melms A, Tolosa E, Weller M, Wiendl H (December 2003). "expression of the B7-related molecule ICOSL by human glioma cells in vitro and in vivo". Glia. 44 (3): 296–301. doi:10.1002/glia.10291. PMID 14603470. 
  • Saatian B, Yu XY, Yu X, Lane AP, Doyle T, Casolaro V, Spannhake EW (July 2004). "Expression of genes for B7-H3 and other T cell ligands by nasal epithelial cells during differentiation and activation". American Journal of Physiology. Lung Cellular and Molecular Physiology. 287 (1): L217–25. doi:10.1152/ajplung.00132.2003. PMID 15047568. 
  • Nakazawa A, Dotan I, Brimnes J, Allez M, Shao L, Tsushima F, Azuma M, Mayer L (May 2004). "The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells". Gastroenterology. 126 (5): 1347–57. doi:10.1053/j.gastro.2004.02.004. PMID 15131796. 

External links[edit]