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ICU may refer to:
- International Cheer Union, the worldwide governing body of cheerleading
- International Cycling Union (Union Cycliste Internationale), the world governing body for sports cycling
- ICU, former Investment Capital Ukraine, Kyiv-based financial group that includes three business areas: trading, investment banking services and asset management.
- Information and Communications University, a research university in Daejeon, South Korea
- Istanbul Commerce University, a private university in Istanbul, Turkey
- International Christian University, a private university (liberal arts college) in Mitaka, Tokyo, Japan
- International Christian University – Kiev, a private university in Kyiv, Ukraine
- Imperial College Union, the students union of Imperial College London
- Industrial and Commercial Workers' Union, a South African political group from the 1920s
- International Clearing Union, a non-existent currency regulatory institution proposed in 1944
- Internationalist Communist Union, an international grouping of Trotskyist political parties
- Islamic Courts Union, an armed group of Sharia courts in Somalia
- Intensive Care Unit, a special department of a hospital or healthcare facility that provides treatment for critically ill patients
- International Components for Unicode, software libraries supporting internationalization
- Intersection Capacity Utilization, a measure of the capacity of a roadway intersection
- Inner City Unit, a British hard edge/punk band
- I.C.U. (film), an unreleased Australian thriller starring Christian Radford
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