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Aliases ID4, IDB4, bHLHb27, inhibitor of DNA binding 4, HLH protein
External IDs MGI: 99414 HomoloGene: 1186 GeneCards: ID4
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ID4
Genomic location for ID4
Band 6p22.3 Start 19,837,386 bp[1]
End 19,840,684 bp[1]
RNA expression pattern
PBB GE ID4 209292 at fs.png

PBB GE ID4 209291 at fs.png

PBB GE ID4 209293 x at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 19.84 – 19.84 Mb Chr 6: 48.26 – 48.27 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

DNA-binding protein inhibitor ID-4 is a protein that in humans is encoded by the ID4 gene.[5][6]


Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative (antimorph) HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins.[6]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172201 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021379 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Pagliuca A, Bartoli PC, Saccone S, Della Valle G, Lania L (Oct 1995). "Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22". Genomics. 27 (1): 200–3. doi:10.1006/geno.1995.1026. PMID 7665172. 
  6. ^ a b "Entrez Gene: ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.