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For the film which uses "ID4" as a marketing initialism, see Independence Day (1996 film).
Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
Symbols ID4 ; IDB4; bHLHb27
External IDs OMIM600581 MGI99414 HomoloGene1186 GeneCards: ID4 Gene
RNA expression pattern
PBB GE ID4 209291 at tn.png
PBB GE ID4 209292 at tn.png
PBB GE ID4 209293 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3400 15904
Ensembl ENSG00000172201 ENSMUSG00000021379
UniProt P47928 P41139
RefSeq (mRNA) NM_001546 NM_031166
RefSeq (protein) NP_001537 NP_112443
Location (UCSC) Chr 6:
19.84 – 19.84 Mb
Chr 13:
48.26 – 48.26 Mb
PubMed search [1] [2]

DNA-binding protein inhibitor ID-4 is a protein that in humans is encoded by the ID4 gene.[1][2]


Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative (antimorph) HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins.[2]

See also[edit]


  1. ^ Pagliuca A, Bartoli PC, Saccone S, Della Valle G, Lania L (Oct 1995). "Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22". Genomics 27 (1): 200–3. doi:10.1006/geno.1995.1026. PMID 7665172. 
  2. ^ a b "Entrez Gene: ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.