IER3

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IER3
Identifiers
AliasesIER3, DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1, immediate early response 3
External IDsMGI: 104814 HomoloGene: 2894 GeneCards: IER3
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for IER3
Genomic location for IER3
Band6p21.33Start30,743,199 bp[1]
End30,744,554 bp[1]
RNA expression pattern
PBB GE IER3 201631 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_052815
NM_003897

NM_133662

RefSeq (protein)

NP_003888

NP_598423

Location (UCSC)Chr 6: 30.74 – 30.74 MbChr 17: 35.82 – 35.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3 gene.[5][6]

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.[7]

References[edit]

  1. ^ a b c ENSG00000137331, ENSG00000206478, ENSG00000235030, ENSG00000227231, ENSG00000230128 GRCh38: Ensembl release 89: ENSG00000237155, ENSG00000137331, ENSG00000206478, ENSG00000235030, ENSG00000227231, ENSG00000230128 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003541 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kondratyev AD, Chung KN, Jung MO (May 1996). "Identification and characterization of a radiation-inducible glycosylated human early-response gene". Cancer Res. 56 (7): 1498–502. PMID 8603392. 
  6. ^ Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF (Aug 1998). "IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival". Science. 281 (5379): 998–1001. doi:10.1126/science.281.5379.998. PMID 9703517. 
  7. ^ "Entrez Gene: IER3 immediate early response 3". 

Further reading[edit]