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Protein IFI16 PDB 2oq0.png
Available structures
PDBHuman UniProt search: PDBe RCSB
AliasesIFI16, IFNGIP1, PYHIN2, interferon gamma inducible protein 16
External IDsMGI: 3695276 HomoloGene: 115929 GeneCards: IFI16
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for IFI16
Genomic location for IFI16
Band1q23.1Start158,999,968 bp[1]
End159,055,155 bp[1]
RNA expression pattern
PBB GE IFI16 208966 x at fs.png

PBB GE IFI16 208965 s at fs.png

PBB GE IFI16 206332 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 159 – 159.06 MbChr 1: 173.57 – 173.6 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.[5][6][7]


This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53,[8][9] retinoblastoma-1 and BRCA1.[10] It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway.[7] IFI16 has been shown to play a role in the sensing of intracellular DNA[11] - a hallmark of virally infected cells - and has also been linked to the death of HIV-infected helper CD4 T cells by pyroptosis, a highly inflammatory form of programmed cell death.[12][13]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163565 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073491 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Trapani JA, Browne KA, Dawson MJ, Ramsay RG, Eddy RL, Show TB, White PC, Dupont B (Oct 1992). "A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells". Immunogenetics. 36 (6): 369–76. doi:10.1007/bf00218044. PMID 1526658.
  6. ^ Trapani JA, Dawson M, Apostolidis VA, Browne KA (Dec 1994). "Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization". Immunogenetics. 40 (6): 415–24. doi:10.1007/bf00177824. PMID 7959953.
  7. ^ a b "Entrez Gene: IFI16 interferon, gamma-inducible protein 16".
  8. ^ Liao, Jack C. C.; Lam, Robert; Brazda, Vaclav; Duan, Shili; Ravichandran, Mani; Ma, Justin; Xiao, Ting; Tempel, Wolfram; Zuo, Xiaobing (2011-03-09). "Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53". Structure. 19 (3): 418–429. doi:10.1016/j.str.2010.12.015. ISSN 1878-4186. PMC 3760383. PMID 21397192.
  9. ^ Ouchi, Mutsuko; Ouchi, Toru (2008-01-01). "Role of IFI16 in DNA damage and checkpoint". Frontiers in Bioscience. 13 (13): 236–239. doi:10.2741/2673. ISSN 1093-9946. PMID 17981541.
  10. ^ Dutta, Dipanjan; Dutta, Sujoy; Veettil, Mohanan Valiya; Roy, Arunava; Ansari, Mairaj Ahmed; Iqbal, Jawed; Chikoti, Leela; Kumar, Binod; Johnson, Karen E. (2015-06-01). "BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses". PLOS Pathogens. 11 (6): e1005030. doi:10.1371/journal.ppat.1005030. ISSN 1553-7374. PMC 4487893. PMID 26121674.
  11. ^ Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG (2010). "IFI16 is an innate immune sensor for intracellular DNA". Nat. Immunol. 11 (11): 997–1004. doi:10.1038/ni.1932. PMC 3142795. PMID 20890285.
  12. ^ Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC (2014). "IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV". Science. 343 (6169): 428–32. doi:10.1126/science.1243640. PMC 3976200. PMID 24356113.
  13. ^ Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC (2014). "Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection". Nature. 505 (7484): 509–14. doi:10.1038/nature12940. PMC 4047036. PMID 24356306.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.