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Interferon, gamma-inducible protein 16
Protein IFI16 PDB 2oq0.png
PDB rendering based on 2oq0.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IFI16 ; IFNGIP1; PYHIN2
External IDs OMIM147586 MGI96429 HomoloGene115929 GeneCards: IFI16 Gene
RNA expression pattern
PBB GE IFI16 206332 s at tn.png
PBB GE IFI16 208965 s at tn.png
PBB GE IFI16 208966 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3428 15950
Ensembl ENSG00000163565 ENSMUSG00000039997
UniProt Q16666 O35368
RefSeq (mRNA) NM_001206567 NM_001045481
RefSeq (protein) NP_001193496 NP_001289578
Location (UCSC) Chr 1:
159 – 159.06 Mb
Chr 1:
173.92 – 173.94 Mb
PubMed search [1] [2]

Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.[1][2][3]


This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway.[3] IFI16 has been shown to play a role in the sensing of intracellular DNA[4] - a hallmark of virally infected cells - and has also been linked to HIV-infected helper T-cell pyroptosis.[5][6]


  1. ^ Trapani JA, Browne KA, Dawson MJ, Ramsay RG, Eddy RL, Show TB, White PC, Dupont B (Oct 1992). "A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells". Immunogenetics 36 (6): 369–76. doi:10.1007/bf00218044. PMID 1526658. 
  2. ^ Trapani JA, Dawson M, Apostolidis VA, Browne KA (Dec 1994). "Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization". Immunogenetics 40 (6): 415–24. doi:10.1007/bf00177824. PMID 7959953. 
  3. ^ a b "Entrez Gene: IFI16 interferon, gamma-inducible protein 16". 
  4. ^ Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG (2010). "IFI16 is an innate immune sensor for intracellular DNA". Nat. Immunol. 11 (11): 997–1004. doi:10.1038/ni.1932. PMC 3142795. PMID 20890285. 
  5. ^ Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC (2014). "IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV". Science 343 (6169): 428–32. doi:10.1126/science.1243640. PMC 3976200. PMID 24356113. 
  6. ^ Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC (2014). "Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection". Nature 505 (7484): 509–14. doi:10.1038/nature12940. PMC 4047036. PMID 24356306. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.