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Protein IGF2BP3 PDB 2e44.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases IGF2BP3, CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3, insulin like growth factor 2 mRNA binding protein 3
External IDs MGI: 1890359 HomoloGene: 4773 GeneCards: IGF2BP3
Gene location (Human)
Chromosome 7 (human)
Chr. Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for IGF2BP3
Genomic location for IGF2BP3
Band 7p15.3 Start 23,310,209 bp[1]
End 23,470,467 bp[1]
RNA expression pattern
PBB GE IGF2BP3 216493 s at fs.png

PBB GE IGF2BP3 203819 s at fs.png

PBB GE IGF2BP3 203820 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 7: 23.31 – 23.47 Mb Chr 6: 49.09 – 49.21 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene.[5][6][7]

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136231 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029814 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development". Mol Cell Biol. 19 (2): 1262–70. PMC 116055Freely accessible. PMID 9891060. 
  6. ^ Mueller-Pillasch F, Lacher U, Wallrapp C, Micha A, Zimmerhackl F, Hameister H, Varga G, Friess H, Buchler M, Beger HG, Vila MR, Adler G, Gress TM (Jul 1997). "Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein". Oncogene. 14 (22): 2729–33. doi:10.1038/sj.onc.1201110. PMID 9178771. 
  7. ^ a b "Entrez Gene: IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3". 

Further reading[edit]