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IKAROS family zinc finger 2 (Helios)
External IDs OMIM606234 MGI1342541 HomoloGene22659 GeneCards: IKZF2 Gene
RNA expression pattern
PBB GE IKZF2 220567 at tn.png
More reference expression data
Species Human Mouse
Entrez 22807 22779
Ensembl ENSG00000030419 ENSMUSG00000025997
UniProt Q9UKS7 P81183
RefSeq (mRNA) NM_001079526 NM_011770
RefSeq (protein) NP_001072994 NP_035900
Location (UCSC) Chr 2:
213 – 213.15 Mb
Chr 1:
69.53 – 69.69 Mb
PubMed search [1] [2]

Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene.[1][2][3]

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.[3]


  1. ^ Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman IL, Fisher AG, Smale ST (Apr 1998). "Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin". Genes Dev 12 (6): 782–96. doi:10.1101/gad.12.6.782. PMC 316626. PMID 9512513. 
  2. ^ Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA (Aug 1998). "Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors". Curr Biol 8 (9): 508–15. doi:10.1016/S0960-9822(98)70202-7. PMID 9560339. 
  3. ^ a b "Entrez Gene: IKZF2 IKAROS family zinc finger 2 (Helios)". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.