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Aliases IKZF3, AIO, AIOLOS, ZNFN1A3, IKAROS family zinc finger 3
External IDs MGI: 1342542 HomoloGene: 8269 GeneCards: 22806
Genetically Related Diseases
Disease Name References
primary biliary cirrhosis
RNA expression pattern
PBB GE IKZF3 221092 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 17: 39.76 – 39.86 Mb Chr 11: 98.46 – 98.55 Mb
PubMed search [2] [3]
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Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene.[4][5][6]


This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.[6]


IKZF3 has been shown to interact with BCL2-like 1[7] and HRAS.[8]


  1. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_12236&geneId=231794". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K (Jun 1997). "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation". EMBO J. 16 (8): 2004–13. doi:10.1093/emboj/16.8.2004. PMC 1169803free to read. PMID 9155026. 
  5. ^ Hosokawa Y, Maeda Y, Takahashi E, Suzuki M, Seto M (Feb 2000). "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping". Genomics. 61 (3): 326–9. doi:10.1006/geno.1999.5949. PMID 10552935. 
  6. ^ a b "Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)". 
  7. ^ Rebollo A, Ayllón V, Fleischer A, Martínez CA, Zaballos A (December 2001). "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis". J. Immunol. 167 (11): 6366–73. doi:10.4049/jimmunol.167.11.6366. PMID 11714801. 
  8. ^ Romero F, Martínez-A C, Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization". EMBO J. 18 (12): 3419–30. doi:10.1093/emboj/18.12.3419. PMC 1171421free to read. PMID 10369681. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.