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Aliases IKZF3, AIO, AIOLOS, ZNFN1A3, IKAROS family zinc finger 3
External IDs MGI: 1342542 HomoloGene: 8269 GeneCards: IKZF3
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for IKZF3
Genomic location for IKZF3
Band 17q12-q21.1 Start 39,757,715 bp[1]
End 39,864,188 bp[1]
RNA expression pattern
PBB GE IKZF3 221092 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 17: 39.76 – 39.86 Mb Chr 17: 98.46 – 98.55 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene.[5][6][7]


This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.[7]


IKZF3 has been shown to interact with BCL2-like 1[8] and HRAS.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000161405 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018168 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K (Jun 1997). "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation". EMBO J. 16 (8): 2004–13. doi:10.1093/emboj/16.8.2004. PMC 1169803Freely accessible. PMID 9155026. 
  6. ^ Hosokawa Y, Maeda Y, Takahashi E, Suzuki M, Seto M (Feb 2000). "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping". Genomics. 61 (3): 326–9. doi:10.1006/geno.1999.5949. PMID 10552935. 
  7. ^ a b "Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)". 
  8. ^ Rebollo A, Ayllón V, Fleischer A, Martínez CA, Zaballos A (December 2001). "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis". J. Immunol. 167 (11): 6366–73. doi:10.4049/jimmunol.167.11.6366. PMID 11714801. 
  9. ^ Romero F, Martínez-A C, Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization". EMBO J. 18 (12): 3419–30. doi:10.1093/emboj/18.12.3419. PMC 1171421Freely accessible. PMID 10369681. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.