IKZF3

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IKZF3
Identifiers
AliasesIKZF3, AIO, AIOLOS, ZNFN1A3, IKAROS family zinc finger 3
External IDsMGI: 1342542 HomoloGene: 8269 GeneCards: IKZF3
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for IKZF3
Genomic location for IKZF3
Band17q12-q21.1Start39,757,718 bp[1]
End39,864,312 bp[1]
RNA expression pattern
PBB GE IKZF3 221092 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_011771

RefSeq (protein)

NP_035901

Location (UCSC)Chr 17: 39.76 – 39.86 MbChr 11: 98.46 – 98.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene.[5][6][7]

Function[edit]

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.[7]

Interactions[edit]

IKZF3 has been shown to interact with BCL2-like 1[8] and HRAS.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000161405 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018168 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K (April 1997). "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation". The EMBO Journal. 16 (8): 2004–13. doi:10.1093/emboj/16.8.2004. PMC 1169803. PMID 9155026.
  6. ^ Hosokawa Y, Maeda Y, Takahashi EI, Suzuki M, Seto M (November 1999). "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping". Genomics. 61 (3): 326–9. doi:10.1006/geno.1999.5949. PMID 10552935.
  7. ^ a b "Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)".
  8. ^ Rebollo A, Ayllón V, Fleischer A, Martínez CA, Zaballos A (December 2001). "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis". Journal of Immunology. 167 (11): 6366–73. doi:10.4049/jimmunol.167.11.6366. PMID 11714801.
  9. ^ Romero F, Martínez-A C, Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization". The EMBO Journal. 18 (12): 3419–30. doi:10.1093/emboj/18.12.3419. PMC 1171421. PMID 10369681.

Further reading[edit]

  • Sun J, Matthias G, Mihatsch MJ, Georgopoulos K, Matthias P (February 2003). "Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice". Journal of Immunology. 170 (4): 1699–706. doi:10.4049/jimmunol.170.4.1699. PMID 12574333.
  • Schmitt C, Tonnelle C, Dalloul A, Chabannon C, Debré P, Rebollo A (June 2002). "Aiolos and Ikaros: regulators of lymphocyte development, homeostasis and lymphoproliferation". Apoptosis. 7 (3): 277–84. doi:10.1023/A:1015372322419. PMID 11997672.
  • Wang JH, Avitahl N, Cariappa A, Friedrich C, Ikeda T, Renold A, Andrikopoulos K, Liang L, Pillai S, Morgan BA, Georgopoulos K (October 1998). "Aiolos regulates B cell activation and maturation to effector state". Immunity. 9 (4): 543–53. doi:10.1016/S1074-7613(00)80637-8. PMID 9806640.
  • Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, Winandy S, Viel A, Sawyer A, Ikeda T, Kingston R, Georgopoulos K (March 1999). "Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes". Immunity. 10 (3): 345–55. doi:10.1016/S1074-7613(00)80034-5. PMID 10204490.
  • Koipally J, Renold A, Kim J, Georgopoulos K (June 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal. 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC 1171390. PMID 10357820.
  • Romero F, Martínez-A C, Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization". The EMBO Journal. 18 (12): 3419–30. doi:10.1093/emboj/18.12.3419. PMC 1171421. PMID 10369681.
  • Koipally J, Georgopoulos K (June 2000). "Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity". The Journal of Biological Chemistry. 275 (26): 19594–602. doi:10.1074/jbc.M000254200. PMID 10766745.
  • Perdomo J, Holmes M, Chong B, Crossley M (December 2000). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". The Journal of Biological Chemistry. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.
  • Rebollo A, Ayllón V, Fleischer A, Martínez CA, Zaballos A (December 2001). "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis". Journal of Immunology. 167 (11): 6366–73. doi:10.4049/jimmunol.167.11.6366. PMID 11714801.
  • Liippo J, Nera KP, Veistinen E, Lähdesmäki A, Postila V, Kimby E, Riikonen P, Hammarström L, Pelkonen J, Lassila O (December 2001). "Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene". European Journal of Immunology. 31 (12): 3469–74. doi:10.1002/1521-4141(200112)31:12<3469::AID-IMMU3469>3.0.CO;2-G. PMID 11745366.
  • Nakase K, Ishimaru F, Fujii K, Tabayashi T, Kozuka T, Sezaki N, Matsuo Y, Harada M (April 2002). "Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia". Experimental Hematology. 30 (4): 313–7. doi:10.1016/S0301-472X(01)00796-2. PMID 11937265.
  • Koipally J, Georgopoulos K (August 2002). "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Antica M, Dubravcic K, Weber I, Raic L, Labar B, Batinic D (February 2007). "A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from patients with leukemia". Haematologica. 92 (2): 260–1. doi:10.3324/haematol.10753. PMID 17296582.
  • Ghadiri A, Duhamel M, Fleischer A, Reimann A, Dessauge F, Rebollo A (April 2007). "Critical function of Ikaros in controlling Aiolos gene expression". FEBS Letters. 581 (8): 1605–16. doi:10.1016/j.febslet.2007.03.025. PMID 17383641.
  • Caballero R, Setien F, Lopez-Serra L, Boix-Chornet M, Fraga MF, Ropero S, Megias D, Alaminos M, Sanchez-Tapia EM, Montoya MC, Esteller M, Gonzalez-Sarmiento R, Ballestar E (August 2007). "Combinatorial effects of splice variants modulate function of Aiolos". Journal of Cell Science. 120 (Pt 15): 2619–30. doi:10.1242/jcs.007344. PMID 17646674.

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.