IKZF4

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IKZF4
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IKZF4, EOS, ZNFN1A4, IKAROS family zinc finger 4
External IDs MGI: 1343139 HomoloGene: 69103 GeneCards: IKZF4
Genetically Related Diseases
vitiligo, type 1 diabetes mellitus, asthma, alopecia areata[1]
RNA expression pattern
PBB GE IKZF4 208472 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022465

NM_011772

RefSeq (protein)

NP_071910

NP_035902.2
NP_035902

Location (UCSC) Chr 12: 56.01 – 56.04 Mb Chr 10: 128.63 – 128.65 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.[4][5]

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM][5]

Interactions[edit]

IKZF4 has been shown to interact with CTBP1[6] and IKZF1.[4][7]

References[edit]

  1. ^ "Diseases that are genetically associated with IKZF4 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b Perdomo J, Holmes M, Chong B, Crossley M (Jan 2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". J Biol Chem. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333. 
  5. ^ a b "Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)". 
  6. ^ Perdomo, José; Crossley Merlin (Dec 2002). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. Germany. 269 (23): 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. ISSN 0014-2956. PMID 12444977. 
  7. ^ Honma, Y; Kiyosawa H; Mori T; Oguri A; Nikaido T; Kanazawa K; Tojo M; Takeda J; Tanno Y; Yokoya S; Kawabata I; Ikeda H; Wanaka A (Mar 1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. NETHERLANDS. 447 (1): 76–80. doi:10.1016/S0014-5793(99)00265-3. ISSN 0014-5793. PMID 10218586. 

Further reading[edit]